Holz, Frank G., Sadda, SriniVas R., Staurenghi, Giovanni ORCID: 0000-0002-2299-5251, Lindner, Moritz ORCID: 0000-0002-4416-3421, Bird, Alan C., Blodi, Barbara A., Bottoni, Ferdinando, Chakravarthy, Usha ORCID: 0000-0002-2606-3734, Chew, Emily Y., Csaky, Karl, Curcio, Christine A., Danis, Ron, Fleckenstein, Monika ORCID: 0000-0001-8321-8037, Freund, K. Bailey ORCID: 0000-0002-7888-9773, Grunwald, Juan, Guymer, Robyn ORCID: 0000-0002-9441-4356, Hoyng, Carel B., Jaffe, Glenn J., Liakopoulos, Sandra, Mones, Jordi M., Oishi, Akio ORCID: 0000-0002-0977-9458, Pauleikhoff, Daniel, Rosenfeld, Philip J., Sarraf, David, Spaide, Richard F., Tadayoni, Ramin, Tufail, Adnan, Wolf, Sebastian ORCID: 0000-0002-7467-7028 and Schmitz-Valckenberg, Steffen (2017). Imaging Protocols in Clinical Studies in Advanced Age-Related Macular Degeneration. Ophthalmology, 124 (4). S. 464 - 479. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1549-4713

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Abstract

Purpose: To summarize the results of 2 consensus meetings (Classification of Atrophy Meeting [ CAM]) on conventional and advanced imaging modalities used to detect and quantify atrophy due to late-stage non-neovascular and neovascular age-related macular degeneration (AMD) and to provide recommendations on the use of these modalities in natural history studies and interventional clinical trials. Design: Systematic debate on the relevance of distinct imaging modalities held in 2 consensus meetings. Participants: A panel of retina specialists. Methods: During the CAM, a consortium of international experts evaluated the advantages and disadvantages of various imaging modalities on the basis of the collective analysis of a large series of clinical cases. A systematic discussion on the role of each modality in future studies in non-neovascular and neovascular AMD was held. Main Outcome Measures: Advantages and disadvantages of current retinal imaging technologies and recommendations for their use in advanced AMD trials. Results: Imaging protocols to detect, quantify, and monitor progression of atrophy should include color fundus photography (CFP), confocal fundus autofluorescence (FAF), confocal near-infrared reflectance (NIR), and high-resolution optical coherence tomography volume scans. These images should be acquired at regular intervals throughout the study. In studies of non-neovascular AMD (without evident signs of active or regressed neo-vascularization [NV] at baseline), CFP may be sufficient at baseline and end-of-study visit. Fluorescein angiography (FA) may become necessary to evaluate for NV at any visit during the study. Indocyanine-green angiography (ICG-A) may be considered at baseline under certain conditions. For studies in patients with neovascular AMD, increased need for visualization of the vasculature must be taken into account. Accordingly, these studies should include FA (recommended at baseline and selected follow-up visits) and ICG-A under certain conditions. Conclusions: A multimodal imaging approach is recommended in clinical studies for the optimal detection and measurement of atrophy and its associated features. Specific validation studies will be necessary to determine the best combination of imaging modalities, and these recommendations will need to be updated as new imaging technologies become available in the future. (C) 2017 by the American Academy of Ophthalmology

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Holz, Frank G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sadda, SriniVas R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Staurenghi, GiovanniUNSPECIFIEDorcid.org/0000-0002-2299-5251UNSPECIFIED
Lindner, MoritzUNSPECIFIEDorcid.org/0000-0002-4416-3421UNSPECIFIED
Bird, Alan C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blodi, Barbara A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bottoni, FerdinandoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chakravarthy, UshaUNSPECIFIEDorcid.org/0000-0002-2606-3734UNSPECIFIED
Chew, Emily Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Csaky, KarlUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Curcio, Christine A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Danis, RonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fleckenstein, MonikaUNSPECIFIEDorcid.org/0000-0001-8321-8037UNSPECIFIED
Freund, K. BaileyUNSPECIFIEDorcid.org/0000-0002-7888-9773UNSPECIFIED
Grunwald, JuanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guymer, RobynUNSPECIFIEDorcid.org/0000-0002-9441-4356UNSPECIFIED
Hoyng, Carel B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaffe, Glenn J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liakopoulos, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mones, Jordi M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oishi, AkioUNSPECIFIEDorcid.org/0000-0002-0977-9458UNSPECIFIED
Pauleikhoff, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosenfeld, Philip J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarraf, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spaide, Richard F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tadayoni, RaminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tufail, AdnanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolf, SebastianUNSPECIFIEDorcid.org/0000-0002-7467-7028UNSPECIFIED
Schmitz-Valckenberg, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-236078
DOI: 10.1016/j.ophtha.2016.12.002
Journal or Publication Title: Ophthalmology
Volume: 124
Number: 4
Page Range: S. 464 - 479
Date: 2017
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1549-4713
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
OPTICAL COHERENCE TOMOGRAPHY; QUANTITATIVE FUNDUS AUTOFLUORESCENCE; GEOGRAPHIC ATROPHY PROGRESSION; SCANNING LASER OPHTHALMOSCOPY; SUBRETINAL DRUSENOID DEPOSITS; INDOCYANINE GREEN ANGIOGRAPHY; RETINAL-PIGMENT EPITHELIUM; GROWTH-FACTOR THERAPY; CHOROIDAL NEOVASCULARIZATION; RETICULAR PSEUDODRUSENMultiple languages
OphthalmologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/23607

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