Universität zu Köln

Scheel, Jennifer, Reber, Sandra, Stoessel, Lisa, Waldmann, Elisabeth ORCID: 0000-0003-3983-9957, Jank, Sabine, Eckardt, Kai-Uwe, Grundmann, Franziska, Vitinius, Frank, de Zwaan, Martina, Bertram, Anna and Erim, Yesim (2017). Patient-reported non-adherence and immunosuppressant trough levels are associated with rejection after renal transplantation. BMC Nephrol., 18. LONDON: BMC. ISSN 1471-2369

Full text not available from this repository.

Abstract

Background: Different measures of non-adherence to immunosuppressant (IS) medication have been found to be associated with rejection episodes after successful transplantation. The aim of the current study was to investigate whether graft rejection after renal transplantation is associated with patient-reported IS medication non-adherence and IS trough level variables (IS trough level variability and percentage of sub-therapeutic IS trough levels). Methods: Patient-reported non-adherence, IS trough level variability, percentage of sub-therapeutic IS trough levels, and acute biopsy-proven late allograft rejections were assessed in 267 adult renal transplant recipients who were = 12 months post-transplantation. Results: The rate of rejection was 13.5%. IS trough level variability, percentage of sub-therapeutic IS trough levels as well as patient-reported non-adherence were all significantly and positively associated with rejection, but not with each other. Logistic regression analyses revealed that only the percentage of sub-therapeutic IS trough levels and age at transplantation remained significantly associated with rejection. Conclusions: Particularly, the percentage of sub-therapeutic IS trough levels is associated with acute rejections after kidney transplantation whereas IS trough level variability and patient-reported non-adherence seem to be of subordinate importance. Patient-reported non-adherence and IS trough level variables were not correlated; thus, non-adherence should always be measured in a multi-methodological approach. Further research concerning the best combination of non-adherence measures is needed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Scheel, Jennifer UNSPECIFIED UNSPECIFIED UNSPECIFIED Reber, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoessel, Lisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Waldmann, Elisabeth UNSPECIFIED orcid.org/0000-0003-3983-9957 UNSPECIFIED Jank, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Eckardt, Kai-Uwe UNSPECIFIED UNSPECIFIED UNSPECIFIED Grundmann, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Vitinius, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED de Zwaan, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Bertram, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Erim, Yesim UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-236245
DOI:	10.1186/s12882-017-0517-6
Journal or Publication Title:	BMC Nephrol.
Volume:	18
Date:	2017
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1471-2369
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SOLID-ORGAN TRANSPLANTATION; KIDNEY-TRANSPLANTATION; MEDICATION ADHERENCE; RISK-FACTORS; SELF-REPORT; GRAFT LOSS; RECIPIENTS; VARIABILITY; TACROLIMUS; IMPACT Multiple languages Urology & Nephrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23624