Universität zu Köln

Lewis, Philip and Erren, Thomas C. (2017). Perinatal Light Imprinting of Circadian Clocks and Systems (PLICCS): The PLICCS and Cancer Hypothesis. Front. Oncol., 7. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2234-943X

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Abstract

Circadian disruption is associated with sleep, mood, and metabolic disorders, andaccording to the International Agency for Research on Cancer-even with cancer. Mechanistically, the source of disease may be circadian system instability which likely arises during development. In animal experiments, both low perinatal light: dark ratios and chronic perinatal photoperiod phase shifting yield enduring, detrimental effects on neuroendocrine physiology via circadian system instability. Certainly, accumulating disturbances to neuroendocrine physiology and detrimental downstream effects could predispose to internal cancers. Epidemiologically, either season of birth or latitude of birth, both of which co-determine perinatal photoperiod-zeitgeber strengths, have been utilized independently as proxies for other environmental co-etiologies of cancer. Both have been independently associated with cancer; however, the evidence is inconclusive. We hypothesize that time of birth and location of birth, together determining perinatal photoperiod, contribute to cancer development through Perinatal Light Imprinting of Circadian Clocks and Systems.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lewis, Philip UNSPECIFIED UNSPECIFIED UNSPECIFIED Erren, Thomas C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-236456
DOI:	10.3389/fonc.2017.00044
Journal or Publication Title:	Front. Oncol.
Volume:	7
Date:	2017
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	2234-943X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LATITUDE; MOOD; RISK; PHOTOPERIOD; INSTABILITY; DARKNESS; HEALTH; RHYTHM; BIRTH Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23645