Universität zu Köln

Epro, Gaspar ORCID: 0000-0002-7241-1533, Mierau, Andreas ORCID: 0000-0002-6305-3260, Doerner, Jonas, Luetkens, Julian A., Scheef, Lukas, Kukuk, Guido M., Boecker, Henning, Maganaris, Constantinos N., Brueggemann, Gert-Peter and Karamanidis, Kiros (2017). The Achilles tendon is mechanosensitive in older adults: adaptations following 14 weeks versus 1.5 years of cyclic strain exercise. J. Exp. Biol., 220 (6). S. 1008 - 1019. CAMBRIDGE: COMPANY OF BIOLOGISTS LTD. ISSN 1477-9145

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Abstract

The aging musculoskeletal system experiences a general decline in structure and function, characterized by a reduced adaptability to environmental stress. We investigated whether the older human Achilles tendon (AT) demonstrates mechanosensitivity (via biomechanical and morphological adaptations) in response to long-term mechanical loading. Thirty-four female adults (60-75 years) were allocated to either a medium-term (14 weeks; N= 21) high AT strain cyclic loading exercise intervention or a control group (N= 13), with 12 participants continuing with the intervention for 1.5 years. AT biomechanical properties were assessed using ultrasonography and dynamometry. Tendon cross-sectional area (CSA) was investigated by means of magnetic resonance imaging. A 22% exercise-related increment in ankle plantarflexion joint moment, along with increased AT stiffness (598.2 +/- 141.2 versus 488.4 +/- 136.9 N mm(-1) at baseline), Young's modulus (1.63 +/- 0.46 versus 1.37 +/- 0.39 GPa at baseline) and about 6% hypertrophy along the entire free AT were identified after 14 weeks of strength training, with no further improvement after 1.5 years of intervention. The aging AT appears to be capable of increasing its stiffness in response to 14 weeks of mechanical loading exercise by changing both its material and dimensional properties. Continuing exercise seems to maintain, but not cause further adaptive changes in tendons, suggesting that the adaptive time-response relationship of aging tendons subjected to mechanical loading is nonlinear.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Epro, Gaspar UNSPECIFIED orcid.org/0000-0002-7241-1533 UNSPECIFIED Mierau, Andreas UNSPECIFIED orcid.org/0000-0002-6305-3260 UNSPECIFIED Doerner, Jonas UNSPECIFIED UNSPECIFIED UNSPECIFIED Luetkens, Julian A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheef, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Kukuk, Guido M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boecker, Henning UNSPECIFIED UNSPECIFIED UNSPECIFIED Maganaris, Constantinos N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brueggemann, Gert-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Karamanidis, Kiros UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-236553
DOI:	10.1242/jeb.146407
Journal or Publication Title:	J. Exp. Biol.
Volume:	220
Number:	6
Page Range:	S. 1008 - 1019
Date:	2017
Publisher:	COMPANY OF BIOLOGISTS LTD
Place of Publication:	CAMBRIDGE
ISSN:	1477-9145
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRICEPS SURAE MUSCLE; HUMAN PATELLAR TENDON; CROSS-SECTIONAL AREA; AGE-RELATED DIFFERENCES; MECHANICAL-PROPERTIES; IN-VIVO; MORPHOLOGICAL PROPERTIES; VISCOELASTIC PROPERTIES; MESSENGER-RNA; MOMENT ARM Multiple languages Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23655