Universität zu Köln

Schaub, Friederike, Enders, Philip ORCID: 0000-0002-9527-4957, Bluhm, Cornelius, Bachmann, Bjoern O., Cursiefen, Claus and Heindl, Ludwig M. (2017). Two-Year Course of Corneal Densitometry After Descemet Membrane Endothelial Keratoplasty. Am. J. Ophthalmol., 175. S. 60 - 68. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1879-1891

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Abstract

PURPOSE: To investigate the 2-year course of corneal densitometry following Descemet membrane endothelial keratoplasty (DMEK) for Fuchs endothelial dystrophy (FED). DESIGN: Retrospective, interventional case series. METHODS: Densitometry values (corneal light back scatter in grayscale units) measured by Scheimpflugbased imaging and clinical records of 160 eyes of 160 patients undergoing DMEK for FED were reviewed. Outcome measures included densitometry data in 4 corneal layers (anterior layer [AL], central layer [CL], posterior layer [PL], and total layer [TL]) and 2 annuli (central annular zone 0-2 mm and peripheral zone 210 mm), central corneal thickness (CCT), best spectacle-corrected visual acuity (BSCVA), and endothelial cell density (ECD) prior to DMEK and at 1, 3, 6, 12, and 24 months postoperatively. RESULTS: Corneal densitometry decreased in all 4 layers over 2 years after DMEK surgery. Regarding TL 0-2 mm, the reduction of corneal light backscatter was statistically significant for all follow-up time points compared with preoperative values (rho < .001) and compared in between follow-up periods (rho <= .010). Corneal light backscatter reduction was significantly higher in the center (0-2 mm) than in the periphery (2-10 mm) for all layers at 12 and 24 months (rho <= .002). ECD and CCT did not correlate with corneal densitometry, whereas BSCVA correlated moderately for TL 0-2 mm (rho = .026; r = 0.449) and TL 210 mm (P =.001; r = 0.585) at 12 months. CONCLUSIONS: Corneal light backscatter showed a significant reduction after DMEK surgery in Fuchs endothelial dystrophy over a period of 2 years, more pronounced in the corneal center, apparently in association with visual acuity improvement. (Am J Ophthalmol 2017;175:60-67. (C) 2016 Elsevier Inc. All rights reserved.)

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schaub, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Enders, Philip UNSPECIFIED orcid.org/0000-0002-9527-4957 UNSPECIFIED Bluhm, Cornelius UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachmann, Bjoern O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-237582
DOI:	10.1016/j.ajo.2016.11.019
Journal or Publication Title:	Am. J. Ophthalmol.
Volume:	175
Page Range:	S. 60 - 68
Date:	2017
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1879-1891
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HIGHER-ORDER ABERRATIONS; KERATOCONUS Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23758