Universität zu Köln

Maier, Franziska, Lewis, Catharine J., Eggers, Carsten, Kuhn, Andrea A., Krug, Henriette, Volkmann, Jens, Kirsch, Anna D., Wojtecki, Lars, Schnitzler, Alfons ORCID: 0000-0002-6414-7939, Deuschl, Guenther, Krauss, Joachim K., Woopen, Christiane and Timmermann, Lars (2017). Development and validation of the deep brain stimulation impairment scale (DBS-IS). Parkinsonism Relat. Disord., 36. S. 69 - 76. OXFORD: ELSEVIER SCI LTD. ISSN 1873-5126

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Abstract

Background: Bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS) has considerable influence on motor and non-motor symptoms in Parkinson's disease (PD). While improvements in motor functioning can be easily assessed with general quality of life questionnaires, the measurement of specific STN-DBS-associated impairments often remains insufficient. Hence, we aimed to develop a questionnaire that measures STN-DBS-related impairments. Methods: The development of the (STN-)DBS Impairment Scale (DBS-IS) consisted of four steps. First, 30 semi-structured interviews before, three and twelve months after STN-DBS-surgery were performed to create 76 items that relate to motor and non-motor functioning in STN-DBS PD patients. Second, pilot testing led to a rewording of the questions for better understanding. Third, a first multicentre survey was performed to reduce items by applying principal component analysis (PCA). Fourth, a second multicentre survey was conducted to examine factor structure, reliability (internal consistency) and validity. Results: After the first survey (N = 215), the PCA lead to a reduction of 54 items. After the second survey (N = 391), exploratory factor analysis determined six factors with 22 items: 1. Postural instability and gait difficulties (5 items), 2. Cognitive impairment (5 items), 3. Speaking problems (3 items), 4. Apathy (3 items), 5. Impulsivity (3 items), and 6. Difficulties related to the DBS device (3 items). High reliability was reported for all subscales (Cronbach's alpha 0.71-0.90). Similarly, construct validity was high (r > 0.50, p < 0.001). Conclusions: With this new questionnaire patients can be followed-up and STN-DBS-specific problems might be adequately measured. Also, comparisons between patients with and without STN-DBS might be possible.(C) 2017 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Maier, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Lewis, Catharine J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, Andrea A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krug, Henriette UNSPECIFIED UNSPECIFIED UNSPECIFIED Volkmann, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirsch, Anna D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wojtecki, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Schnitzler, Alfons UNSPECIFIED orcid.org/0000-0002-6414-7939 UNSPECIFIED Deuschl, Guenther UNSPECIFIED UNSPECIFIED UNSPECIFIED Krauss, Joachim K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Woopen, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-237718
DOI:	10.1016/j.parkreldis.2017.01.002
Journal or Publication Title:	Parkinsonism Relat. Disord.
Volume:	36
Page Range:	S. 69 - 76
Date:	2017
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1873-5126
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUBTHALAMIC NUCLEUS STIMULATION; QUALITY-OF-LIFE; PARKINSONS-DISEASE; APATHY; INVENTORY Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23771