Universität zu Köln

Hermann, B., Lehners, N., Brodhun, M., Boden, K., Hochhaus, A., Kochanek, M., Meckel, K., Mayer, K., Rachow, T., Rieger, C., Schalk, E., Weber, T., Schmeier-Juerchott, A., Schlattmann, P., Teschner, D. and von Lilienfeld-Toal, M. (2017). Influenza virus infections in patients with malignancies - characteristics and outcome of the season 2014/15. A survey conducted by the Infectious Diseases Working Party (AGIHO) of the German Society of Haematology and Medical Oncology (DGHO). Eur. J. Clin. Microbiol. Infect. Dis., 36 (3). S. 565 - 574. NEW YORK: SPRINGER. ISSN 1435-4373

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Abstract

Influenza virus infections (IVI) may pose a vital threat to immunocompromised patients such as those suffering from malignancies, but specific data on epidemiology and outcome in these patients are scarce. In this study, we collected data on patients with active cancer or with a history of cancer, presenting with documented IVI in eight centres in Germany. Two hundred and three patients were identified, suffering from haematological malignancies or solid tumours; 109 (54 %) patients had active malignant disease. Influenza A was detected in 155 (77 %) and Influenza B in 46 (23 %) of patients (genera not determined in two patients). Clinical symptoms were consistent with upper respiratory tract infection in 55/203 (27 %), influenza-like illness in 82/203 (40 %), and pneumonia in 67/203 (33 %). Anti-viral treatment with oseltamivir was received by 116/195 (59 %). Superinfections occurred in 37/203 (18 %), and admission on an intensive care unit was required in 26/203 (13 %). Seventeen patients (9 %) died. Independent risk factors for death were delayed diagnosis of IVI and bacterial or fungal superinfection, but not underlying malignancy or ongoing immunosuppression. In conclusion, patients with IVI show high rates of pneumonia and mortality. Early and rapid diagnosis is essential. The high rate of pneumonia and superinfections should be taken into account when managing IVI in these patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hermann, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehners, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brodhun, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boden, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hochhaus, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kochanek, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meckel, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mayer, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rachow, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rieger, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schalk, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmeier-Juerchott, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlattmann, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Teschner, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED von Lilienfeld-Toal, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-238571
DOI:	10.1007/s10096-016-2833-3
Journal or Publication Title:	Eur. J. Clin. Microbiol. Infect. Dis.
Volume:	36
Number:	3
Page Range:	S. 565 - 574
Date:	2017
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1435-4373
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM-CELL TRANSPLANTATION; RESPIRATORY-TRACT INFECTIONS; BACTERIAL PNEUMONIA; PANDEMIC INFLUENZA; COMPLICATIONS; OSELTAMIVIR; GUIDELINES; RECIPIENTS; PATHOGENS; THERAPY Multiple languages Infectious Diseases; Microbiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23857