Ranjbar, Mahdy, Schneider, Toni, Brand, Carl, Grisanti, Salvatore, Lueke, Julia and Lueke, Matthias (2017). The effect of anakinra on retinal function in isolated perfused vertebrate retina. J. Curr. Ophthalmol., 29 (1). S. 69 - 72. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 2452-2325
Full text not available from this repository.Abstract
Purpose: Blockage of the interleukin 1 (IL-1) signaling pathway has been proposed for treatment of inflammatory disorders like those affecting the retina and its adjacent tissue. Herein, we evaluated one of those inhibitory drugs, anakinra (Kineret (R)), based on its safety profile with emphasis on retinal function from an electrophysiological point of view. Methods: Bovine retina preparations were perfused with two different concentrations of anakinra (1 mg/ml and 2 mg/ml). An electroretinogram (ERG) was recorded and b-wave recovery assessed. Results: Exposure to anakinra at a concentration of 1 mg/ml did not decrease the b-wave amplitude, whereas 2 mg/ml resulted in a significant reduction. Conclusions: Based on these preliminary results, anakinra at a dose as low as 1 mg/ml could be regarded as safe for retinal function. However, dosages of 2 mg/ml and more do have toxic electrophysiological effects, at least for the short-term. Copyright (C) 2016, Iranian Society of Ophthalmology. Production and hosting by Elsevier B.V.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||
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| URN: | urn:nbn:de:hbz:38-239111 | ||||||||||||||||||||||||||||
| DOI: | 10.1016/j.joco.2016.12.002 | ||||||||||||||||||||||||||||
| Journal or Publication Title: | J. Curr. Ophthalmol. | ||||||||||||||||||||||||||||
| Volume: | 29 | ||||||||||||||||||||||||||||
| Number: | 1 | ||||||||||||||||||||||||||||
| Page Range: | S. 69 - 72 | ||||||||||||||||||||||||||||
| Date: | 2017 | ||||||||||||||||||||||||||||
| Publisher: | ELSEVIER SCIENCE BV | ||||||||||||||||||||||||||||
| Place of Publication: | AMSTERDAM | ||||||||||||||||||||||||||||
| ISSN: | 2452-2325 | ||||||||||||||||||||||||||||
| Language: | English | ||||||||||||||||||||||||||||
| Faculty: | Unspecified | ||||||||||||||||||||||||||||
| Divisions: | Unspecified | ||||||||||||||||||||||||||||
| Subjects: | no entry | ||||||||||||||||||||||||||||
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| Refereed: | Yes | ||||||||||||||||||||||||||||
| URI: | http://kups.ub.uni-koeln.de/id/eprint/23911 |
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