Marks, Florian ORCID: 0000-0002-6043-7170, von Kalckreuth, Vera, Aaby, Peter ORCID: 0000-0001-8331-1389, Adu-Sarkodie, Yaw, El Tayeb, Muna Ahmed, Ali, Mohammad ORCID: 0000-0003-1410-388X, Aseffa, Abraham ORCID: 0000-0002-8028-1150, Baker, Stephen, Biggs, Holly M., Bjerregaard-Andersen, Morten, Breiman, Robert F., Campbell, James I., Cosmas, Leonard, Crump, John A. ORCID: 0000-0002-4529-102X, Espinoza, Maria Cruz, Deerin, Jessica Fung, Dekker, Denise Myriam, Fields, Barry S., Gasmelseed, Nagla, Hertz, Julian T., Jaeger, Justin Im Anna, Jeon, Hyon Jin, Kabore, Leon Parfait, Keddy, Karen H., Konings, Frank, Krumkamp, Ralf, Ley, Benedikt, Erg, Sandra Valborg Lofb, May, Juergen, Meyer, Christian G., Mintz, Eric D., Montgomery, Joel M., Niang, Aissatou Ahmet, Nichols, Chelsea, Olack, Beatrice, Pak, Gi Deok, Panzner, Ursula, Park, Jin Kyung, Park, Se Eun, Rabezanahary, Henintsoa, Rakotozandrindrainy, Raphael, Raminosoa, Tiana Mirana, Razafindrabe, Tsiriniaina Jean Luco, Sampo, Emmanuel, Schutt-Gerowitt, Heidi, Sow, Amy Gassama, Sarpong, Nimako, Seo, Hye Jin, Sooka, Arvinda, Soura, Abdramane Bassiahi, Tall, Adama, Teferi, Mekonnen, Thriemer, Kamala, Warren, Michelle R., Yeshitela, Biruk, Clemens, John D. and Wierzba, Thomas F. (2017). Incidence of invasive salmonella disease in sub-Saharan Africa: a multicentre population-based surveillance study. Lancet Glob. Health, 5 (3). S. E310 - 14. OXFORD: ELSEVIER SCI LTD. ISSN 2214-109X

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Abstract

Background Available incidence data for invasive salmonella disease in sub-Saharan Africa are scarce. Standardised, multicountry data are required to better understand the nature and burden of disease in Africa. We aimed to measure the adjusted incidence estimates of typhoid fever and invasive non-typhoidal salmonella (iNTS) disease in sub-Saharan Africa, and the antimicrobial susceptibility profiles of the causative agents. Methods We established a systematic, standardised surveillance of blood culture-based febrile illness in 13 African sentinel sites with previous reports of typhoid fever: Burkina Faso (two sites), Ethiopia, Ghana, Guinea-Bissau, Kenya, Madagascar (two sites), Senegal, South Africa, Sudan, and Tanzania (two sites). We used census data and health-care records to define study catchment areas and populations. Eligible participants were either inpatients or outpatients who resided within the catchment area and presented with tympanic (>= 38.0 degrees C) or axillary temperature (>= 37.5 degrees C). Inpatients with a reported history of fever for 72 h or longer were excluded. We also implemented a health-care utilisation survey in a sample of households randomly selected from each study area to investigate health-seeking behaviour in cases of self-reported fever lasting less than 3 days. Typhoid fever and iNTS disease incidences were corrected for health-care-seeking behaviour and recruitment. Findings Between March 1, 2010, and Jan 31, 2014, 135 Salmonella enterica serotype Typhi (S Typhi) and 94 iNTS isolates were cultured from the blood of 13 431 febrile patients. Salmonella spp accounted for 33% or more of all bacterial pathogens at nine sites. The adjusted incidence rate (AIR) of S Typhi per 100 000 person-years of observation ranged from 0 (95% CI 0-0) in Sudan to 383 (274-535) at one site in Burkina Faso; the AIR of iNTS ranged from 0 in Sudan, Ethiopia, Madagascar (Isotry site), and South Africa to 237 (178-316) at the second site in Burkina Faso. The AIR of iNTS and typhoid fever in individuals younger than 15 years old was typically higher than in those aged 15 years or older. Multidrug-resistant S Typhi was isolated in Ghana, Kenya, and Tanzania (both sites combined), and multidrug-resistant iNTS was isolated in Burkina Faso (both sites combined), Ghana, Kenya, and Guinea-Bissau. Interpretation Typhoid fever and iNTS disease are major causes of invasive bacterial febrile illness in the sampled locations, most commonly affecting children in both low and high population density settings. The development of iNTS vaccines and the introduction of S Typhi conjugate vaccines should be considered for high-incidence settings, such as those identified in this study. Copyright (C) The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Marks, FlorianUNSPECIFIEDorcid.org/0000-0002-6043-7170UNSPECIFIED
von Kalckreuth, VeraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aaby, PeterUNSPECIFIEDorcid.org/0000-0001-8331-1389UNSPECIFIED
Adu-Sarkodie, YawUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
El Tayeb, Muna AhmedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ali, MohammadUNSPECIFIEDorcid.org/0000-0003-1410-388XUNSPECIFIED
Aseffa, AbrahamUNSPECIFIEDorcid.org/0000-0002-8028-1150UNSPECIFIED
Baker, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biggs, Holly M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bjerregaard-Andersen, MortenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Breiman, Robert F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Campbell, James I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cosmas, LeonardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crump, John A.UNSPECIFIEDorcid.org/0000-0002-4529-102XUNSPECIFIED
Espinoza, Maria CruzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deerin, Jessica FungUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dekker, Denise MyriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fields, Barry S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gasmelseed, NaglaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hertz, Julian T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaeger, Justin Im AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jeon, Hyon JinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kabore, Leon ParfaitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keddy, Karen H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Konings, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krumkamp, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ley, BenediktUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erg, Sandra Valborg LofbUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
May, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, Christian G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mintz, Eric D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montgomery, Joel M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niang, Aissatou AhmetUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nichols, ChelseaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olack, BeatriceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pak, Gi DeokUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Panzner, UrsulaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Park, Jin KyungUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Park, Se EunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rabezanahary, HenintsoaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rakotozandrindrainy, RaphaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raminosoa, Tiana MiranaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Razafindrabe, Tsiriniaina Jean LucoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sampo, EmmanuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schutt-Gerowitt, HeidiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sow, Amy GassamaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarpong, NimakoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seo, Hye JinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sooka, ArvindaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soura, Abdramane BassiahiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tall, AdamaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teferi, MekonnenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thriemer, KamalaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Warren, Michelle R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yeshitela, BirukUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clemens, John D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wierzba, Thomas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-239230
DOI: 10.1016/S2214-109X(17)30022-0
Journal or Publication Title: Lancet Glob. Health
Volume: 5
Number: 3
Page Range: S. E310 - 14
Date: 2017
Publisher: ELSEVIER SCI LTD
Place of Publication: OXFORD
ISSN: 2214-109X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ENTERICA SEROVAR TYPHI; LABORATORY DIAGNOSIS; FEVER; KENYA; COUNTRIES; CHILDREN; BURDEN; BLOOD; SENSITIVITY; INFECTIONSMultiple languages
Public, Environmental & Occupational HealthMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/23923

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