Universität zu Köln

Zange, Jochen ORCID: 0000-0003-1822-0952, Schopen, Kathrin, Albracht, Kirsten ORCID: 0000-0002-4271-2511, Gerlach, Darius A., Frings-Meuthen, Petra, Maffiuletti, Nicola A. ORCID: 0000-0001-5670-286X, Bloch, Wilhelm and Rittweger, Joern (2017). Using the Hephaistos orthotic device to study countermeasure effectiveness of neuromuscular electrical stimulation and dietary lupin protein supplementation, a randomised controlled trial. PLoS One, 12 (2). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Purpose The present study investigated whether neuromuscular electrical stimulation for 20 min twice a day with an electrode placed over the soleus muscle and nutritional supplementation with 19 g of protein rich lupin seeds can reduce the loss in volume and strength of the human calf musculature during long term unloading by wearing an orthotic unloading device. Methods Thirteen healthy male subjects (age of 26.4 +/- 3.7 years) wore a Hephaistos orthosis one leg for 60 days during all habitual activities. The leg side was randomly chosen for every subject. Six subjects only wore the orthosis as control group, and 7 subjects additionally received the countermeasure consisting of neuromuscular electrical stimulation of the soleus and lateral gastrocnemius muscles and lupin protein supplementation. Twenty-eight days before and on the penultimate day of the intervention cross-sectional images of the calf muscles were taken by magnetic resonance imaging (controls n = 5), and maximum voluntary torque (controls n = 6) of foot plantar flexion was estimated under isometric (extended knee, 90 degrees knee flexion) and isokinetic conditions (extended knee), respectively. Results After 58 days of wearing the orthosis the percentage loss of volume in the entire triceps surae muscle of the control subjects (-11.9 +/- 4.4%, mean +/- standard deviation) was reduced by the countermeasure (-3.5 +/- 7.2%, p = 0.032). Wearing the orthosis generally reduced plantar flexion torques values, however, only when testing isometric contraction at 90 degrees knee ankle the countermeasure effected a significantly lower percentage decrease of torque (-9.7 +/- 7.2%, mean + SD) in comparison with controls (-22.3 +/- 11.2%, p = 0.032). Conclusion Unloading of calf musculature by an orthotic device resulted in the expected loss of muscle volume and maximum of plantar flexion torque. Neuromuscular electrical muscle stimulation and lupin protein supplementation could significantly reduce the process of atrophy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zange, Jochen UNSPECIFIED orcid.org/0000-0003-1822-0952 UNSPECIFIED Schopen, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Albracht, Kirsten UNSPECIFIED orcid.org/0000-0002-4271-2511 UNSPECIFIED Gerlach, Darius A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Frings-Meuthen, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Maffiuletti, Nicola A. UNSPECIFIED orcid.org/0000-0001-5670-286X UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Rittweger, Joern UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-239665
DOI:	10.1371/journal.pone.0171562
Journal or Publication Title:	PLoS One
Volume:	12
Number:	2
Date:	2017
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MUSCLE DISUSE ATROPHY; WHEY-PROTEIN; BONE LOSS; BED REST; METABOLIC-ACIDOSIS; BODY-COMPOSITION; SPACE-FLIGHT; RAT MUSCLE; EXERCISE; VOLUME Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23966