Universität zu Köln

Barton, Ann Kristin, Heinemann, Henrike, Schenk, Ina, Machnik, Marc and Gehlen, Heidrun (2017). Influence of respiratory tract disease and mode of inhalation on detectability of budesonide in equine urine and plasma. Am. J. Vet. Res., 78 (2). S. 244 - 251. SCHAUMBURG: AMER VETERINARY MEDICAL ASSOC. ISSN 1943-5681

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Abstract

OBJECTIVE To evaluate the influence of respiratory tract disease (ie, recurrent airway obstruction [RAO]) and mode of inhalation on detectability of inhaled budesonide in equine plasma and urine samples. ANIMALS 16 horses (8 healthy control horses and 8 horses affected by RAO, as determined by results of clinical examination, blood gas analysis, bronchoscopy, and cytologic examination of bronchoalveolar lavage fluid). PROCEDURES 4 horses of each group inhaled budesonide (3 mu g/kg) twice daily for 10 days while at rest, and the remaining 4 horses of each group inhaled budesonide during lunging exercise. Plasma and urine samples were obtained 4 to 96 hours after inhalation and evaluated for budesonide and, in urine samples, the metabolites 6 beta-hydroxybudesonide and 16 alpha-hydroxyprednisolone. RESULTS Detected concentrations of budesonide were significantly higher at all time points for RAO-affected horses, compared with concentrations for the control horses. All samples of RAO-affected horses contained budesonide concentrations above the limit of detection at 96 hours after inhalation, whereas this was found for only 2 control horses. Detected concentrations of budesonide were higher, but not significantly so, at all time points in horses that inhaled budesonide during exercise, compared with concentrations for inhalation at rest. CONCLUSIONS AND CLINICAL RELEVANCE Results of this study indicated that the time interval between inhalation of a glucocorticoid and participation in sporting events should be increased when inhalation treatment is administered during exercise to horses affected by respiratory tract disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Barton, Ann Kristin UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinemann, Henrike UNSPECIFIED UNSPECIFIED UNSPECIFIED Schenk, Ina UNSPECIFIED UNSPECIFIED UNSPECIFIED Machnik, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Gehlen, Heidrun UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-240211
DOI:	10.2460/ajvr.78.2.244
Journal or Publication Title:	Am. J. Vet. Res.
Volume:	78
Number:	2
Page Range:	S. 244 - 251
Date:	2017
Publisher:	AMER VETERINARY MEDICAL ASSOC
Place of Publication:	SCHAUMBURG
ISSN:	1943-5681
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RECURRENT AIRWAY-OBSTRUCTION; FLUTICASONE PROPIONATE; HORSES; BRONCHOCONSTRICTION; PHARMACOKINETICS; EXERCISE; HEAVES; COPD Multiple languages Veterinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24021