Universität zu Köln

Farag, Mina, Patil, Nikhil Prakash, Sabashnikov, Anton, Arif, Rawa, Szabo, Gabor, Kallenbach, Klaus, Ruhparwar, Arjang, Karck, Matthias, Brenner, Thorsten, Hofer, Stefan and Weymann, Alexander (2017). Comparison of Two Miniaturized Cardiopulmonary Bypass Systems Regarding Inflammatory Response. Artif. Organs, 41 (2). S. 139 - 146. HOBOKEN: WILEY. ISSN 1525-1594

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Abstract

Cardiopulmonary bypass (CPB) is a known mediator of systemic inflammatory response. Extracorporeal circulations are undergoing continuous modifications and optimizations to achieve better results. Hence we aim to compare the inflammatory response associated with two recent miniature extracorporeal circulation systems during normothermic CPB. We measured plasma levels of cytokines including interleukin (IL)-1 beta, IL-6, IL-10, tumor necrosis factor-alpha, migration inhibitory factor (MIF), receptor for advanced glycation endproduct, and cluster of differentiation 40 ligand in 60 consecutive patients during the first 24 h after CPB. The patients were prospectively randomized to one of three trial groups: patients in group A were operated with the minimal extracorporeal circulation circuit (MECC, Maquet, Rastatt, Germany), group B operated with the extracorporeal circulation circuit optimized (ECC.O, Sorin, Italy), and group C operated with a conventional extracorporeal circuit (CECC, Maquet). Arterial blood samples were collected at intervals before, 30 min after initiation, and after termination of CPB. Further samples were collected 6 and 24 h after CPB. IL-10 levels were significantly raised in the CECC group as compared with either of the mini ECC-circuits with a peak concentration at 6 h postoperatively. Human MIF concentrations were significantly higher in the CECC group starting 30 min after CPB and peaking at the end of CPB. The overall reduction in cytokine concentrations in the mini-ECC groups correlated with a lower need for blood transfusion in MECC and a shorter mechanical ventilation time for ECC.O. Normothermic CPB using minimally invasive extracorporeal circulation circuits can reduce the inflammatory response as measured by cytokine levels, which may be beneficial for perioperative preservation of pulmonary function and hemostasis in low risk patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Farag, Mina UNSPECIFIED UNSPECIFIED UNSPECIFIED Patil, Nikhil Prakash UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabashnikov, Anton UNSPECIFIED UNSPECIFIED UNSPECIFIED Arif, Rawa UNSPECIFIED UNSPECIFIED UNSPECIFIED Szabo, Gabor UNSPECIFIED UNSPECIFIED UNSPECIFIED Kallenbach, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhparwar, Arjang UNSPECIFIED UNSPECIFIED UNSPECIFIED Karck, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Brenner, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Hofer, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Weymann, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-240291
DOI:	10.1111/aor.12750
Journal or Publication Title:	Artif. Organs
Volume:	41
Number:	2
Page Range:	S. 139 - 146
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1525-1594
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXTRACORPOREAL-CIRCULATION SYSTEM; MIGRATION INHIBITORY FACTOR; OFF-PUMP; ON-PUMP; SURGERY; CIRCUIT Multiple languages Engineering, Biomedical; Transplantation Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24029