Universität zu Köln

Felsch, Moritz, Zaim, Souhil, Dicken, Volker, Lehmacher, Walter and Scheuring, Urban J. (2017). Comparison of central and local serial CT assessments of metastatic renal cell carcinoma patients in a clinical phase IIB study. Acta Radiol., 58 (2). S. 249 - 256. LONDON: SAGE PUBLICATIONS LTD. ISSN 1600-0455

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Abstract

Background: Clinical oncological studies attempt to improve precision of data by central radiological assessments. However, it is unclear, to which extent local and central assessments diverge. Purpose: To quantify inter-reader variability and the deviation of local from central radiological assessments of computed tomography (CT) scans. Material and Methods: This was a sub-study of a randomized clinical phase IIb trial in metastatic renal cell carcinoma (RCC), comparing first-line sorafenib with interferon-alpha-2a (IFN-alpha-2a). It analyzed agreements of local with central RECIST CT assessments by Cohen's kappa (kappa), symmetry tests, deviations in waterfall plots, Bland-Altman plots, and parametric survival analyses. Conclusion: These data suggest that central radiologic review may reduce technical measurement variability in clinical trials, which should be scrutinized in future studies compared to a volumetric reference.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Felsch, Moritz UNSPECIFIED UNSPECIFIED UNSPECIFIED Zaim, Souhil UNSPECIFIED UNSPECIFIED UNSPECIFIED Dicken, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmacher, Walter UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheuring, Urban J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-240815
DOI:	10.1177/0284185116642634
Journal or Publication Title:	Acta Radiol.
Volume:	58
Number:	2
Page Range:	S. 249 - 256
Date:	2017
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
ISSN:	1600-0455
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PULMONARY METASTASES; GROWTH THRESHOLD; SOLID TUMORS; CRITERIA; RECIST; VARIABILITY; VOLUMETRY; CANCER Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24081