Universität zu Köln

Austermann, Christian, Schierwagen, Robert ORCID: 0000-0002-2195-3666, Mohr, Raphael, Anadol, Evrim, Klein, Sabine ORCID: 0000-0001-6691-2895, Pohlmann, Alessandra, Jansen, Christian, Strassburg, Christian P., Schwarze-Zander, Carolynne, Boesecke, Christoph, Rockstroh, Juergen K., Odenthal, Margarete and Trebicka, Jonel (2017). microRNA-200a: A Stage-Dependent Biomarker and Predictor of Steatosis and Liver Cell Injury in Human Immunodeficiency Virus Patients. Hepatol. Commun., 1 (1). S. 36 - 46. CHICHESTER: JOHN WILEY & SONS LTD. ISSN 2471-254X

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Abstract

Nonalcoholic fatty liver disease contributes to liver-related mortality and has a high prevalence among patients with human immunodeficiency virus (HIV). The early detection of steatosis could prevent disease progression through life-style changes. However, as the common serum markers are nonspecific and the gold standard for the detection of nonalcoholic fatty liver disease remains the invasive liver biopsy, its verification is limited. Therefore, the search for novel biomarkers is essential. Several studies have emphasized the role of microRNAs (miRNAs) as biomarkers for certain liver diseases. With our study, we aimed to investigate the potential of miR-200a as a biomarker for liver injury, fibrosis, and steatosis in HIV patients. The study cohort consisted of 89 HIV patients. Clinical and laboratory parameters were assessed twice, within a median follow-up period of 12 months. miR-200a serum levels were determined by real-time polymerase chain reaction and normalized to spiked-in RNA (SV40). miR-200a serum levels showed a significant correlation with the patients' controlled attenuation parameter scores and their body weight at baseline and with alanine aminotransferase serum levels at follow-up. At baseline, we observed a stage-dependent increase in miR-200a serum levels according to the degree of steatosis. More importantly, patients with higher baseline levels of miR-200a recorded a progression of steatosis at follow-up. Remarkably, miR-200a not only reveals a prognostic value for steatosis but possibly also for liver damage and metabolic adaptions as patients with an increase in alanine aminotransferase/aspartate aminotransferase serum levels over time also recorded higher baseline miR-200a levels. Conclusion: Our study reveals miR-200a not only to be a stage-dependent biomarker of steatosis but also to be a predictor of steatosis progression and probably liver cell injury in HIV patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Austermann, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Schierwagen, Robert UNSPECIFIED orcid.org/0000-0002-2195-3666 UNSPECIFIED Mohr, Raphael UNSPECIFIED UNSPECIFIED UNSPECIFIED Anadol, Evrim UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Sabine UNSPECIFIED orcid.org/0000-0001-6691-2895 UNSPECIFIED Pohlmann, Alessandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Jansen, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Strassburg, Christian P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwarze-Zander, Carolynne UNSPECIFIED UNSPECIFIED UNSPECIFIED Boesecke, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Rockstroh, Juergen K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Odenthal, Margarete UNSPECIFIED UNSPECIFIED UNSPECIFIED Trebicka, Jonel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-241678
DOI:	10.1002/hep4.1017
Journal or Publication Title:	Hepatol. Commun.
Volume:	1
Number:	1
Page Range:	S. 36 - 46
Date:	2017
Publisher:	JOHN WILEY & SONS LTD
Place of Publication:	CHICHESTER
ISSN:	2471-254X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SIMPLE NONINVASIVE INDEX; ANTIRETROVIRAL THERAPY; HEPATOCELLULAR-CARCINOMA; SIGNIFICANT FIBROSIS; HEPATIC STEATOSIS; EXPRESSION; DISEASE; PREVALENCE; MORTALITY; CIRRHOSIS Multiple languages Gastroenterology & Hepatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24167