Universität zu Köln

Trempler, Ima, Schiffer, Anne-Marike, El-Sourani, Nadiya, Ahlheim, Christiane, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Schubotz, Ricarda I. (2017). Frontostriatal Contribution to the Interplay of Flexibility and Stability in Serial Prediction. J. Cogn. Neurosci., 29 (2). S. 298 - 310. CAMBRIDGE: MIT PRESS. ISSN 1530-8898

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Abstract

Surprising events may be relevant or irrelevant for behavior, requiring either flexible adjustment or stabilization of our model of the world and according response strategies. Cognitive flexibility and stability in response to environmental demands have been described as separable cognitive states, associated with activity of striatal and lateral prefrontal regions, respectively. It so far remains unclear, however, whether these two states act in an antagonistic fashion and which neural mechanisms mediate the selection of respective responses, on the one hand, and a transition between these states, on the other. In this study, we tested whether the functional dichotomy between striatal and prefrontal activity applies for the separate functions of updating (in response to changes in the environment, i.e., switches) and shielding (in response to chance occurrences of events violating expectations, i.e., drifts) of current predictions. We measured brain activity using fMRI while 20 healthy participants performed a task that required to serially predict upcoming items. Switches between predictable sequences had to be indicated via button press while sequence omissions (drifts) had to be ignored. We further varied the probability of switches and drifts to assess the neural network supporting the transition between flexible and stable cognitive states as a function of recent performance history in response to environmental demands. Flexible switching between models was associated with activation in medial pFC (BA 9 and BA 10), whereas stable maintenance of the internal model corresponded to activation in the lateral pFC (BA 6 and inferior frontal gyrus). Our findings extend previous studies on the interplay of flexibility and stability, suggesting that different prefrontal regions are activated by different types of prediction errors, dependent on their behavioral requirements. Furthermore, we found that striatal activation in response to switches and drifts was modulated by participants' successful behavior toward these events, suggesting the striatum to be responsible for response selections following unpredicted stimuli. Finally, we observed that the dopaminergic midbrain modulates the transition between different cognitive states, thresholded by participants' individual performance history in response to temporal environmental demands.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Trempler, Ima UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiffer, Anne-Marike UNSPECIFIED UNSPECIFIED UNSPECIFIED El-Sourani, Nadiya UNSPECIFIED UNSPECIFIED UNSPECIFIED Ahlheim, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Schubotz, Ricarda I. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-241723
DOI:	10.1162/jocn_a_01040
Journal or Publication Title:	J. Cogn. Neurosci.
Volume:	29
Number:	2
Page Range:	S. 298 - 310
Date:	2017
Publisher:	MIT PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1530-8898
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language WORKING-MEMORY; PREFRONTAL CORTEX; DOPAMINERGIC CONTROL; COGNITIVE CONTROL; SYSTEM; MODELS; EXPLOITATION; MODULATION; HYPOTHESIS; STRIATUM Multiple languages Neurosciences; Psychology, Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24172