Universität zu Köln

Rulli, Giuseppe, Duangdee, Nongnaphat, Hummel, Werner, Berkessel, Albrecht ORCID: 0000-0003-0470-7428 and Groeger, Harald (2017). First Tandem-Type One-Pot Process Combining Asymmetric Organo- and Biocatalytic Reactions in Aqueous Media Exemplified for the Enantioselective and Diastereoselective Synthesis of 1,3-Diols. Eur. J. Org. Chem., 2017 (4). S. 812 - 818. WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1099-0690

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Abstract

A suitable process window was identified for the combination of an asymmetric organocatalytic aldol reaction and subsequent biocatalytic reduction in aqueous medium, which thus enabled the enantio- and diastereoselective synthesis of 1,3-diols in a tandem-type, one-pot process. A key feature of this one-pot synthesis is the high 500 mM loading of the aldehyde substrate used as a starting material.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rulli, Giuseppe UNSPECIFIED UNSPECIFIED UNSPECIFIED Duangdee, Nongnaphat UNSPECIFIED UNSPECIFIED UNSPECIFIED Hummel, Werner UNSPECIFIED UNSPECIFIED UNSPECIFIED Berkessel, Albrecht UNSPECIFIED orcid.org/0000-0003-0470-7428 UNSPECIFIED Groeger, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-242197
DOI:	10.1002/ejoc.201600831
Journal or Publication Title:	Eur. J. Org. Chem.
Volume:	2017
Number:	4
Page Range:	S. 812 - 818
Date:	2017
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	1099-0690
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Organic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DYNAMIC KINETIC RESOLUTION; ENZYMATIC RESOLUTION; SECONDARY ALCOHOLS; COMBINATION; RACEMIZATION; CATALYSTS; ORGANOCATALYSIS Multiple languages Chemistry, Organic Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24219