Universität zu Köln

Wang, Qing, De Luca, Andrea ORCID: 0000-0002-9561-9193, Smith, Colette ORCID: 0000-0003-2847-3355, Zangerle, Robert, Sambatakou, Helen, Bonnet, Fabrice, Smit, Colette, Schommers, Philipp ORCID: 0000-0003-3375-6800, Thornton, Alicia, Berenguer, Juan ORCID: 0000-0001-8541-8200, Peters, Lars, Spagnuolo, Vincenzo ORCID: 0000-0002-9656-7217, Ammassari, Adriana ORCID: 0000-0002-0284-0340, Antinori, Andrea ORCID: 0000-0003-2121-4684, Roldan, Eugenia Quiros, Mussini, Cristina, Miro, Jose M., Konopnicki, Deborah, Fehr, Jan, Campbell, Maria A., Termote, Monique and Bucher, Heiner C. (2017). Chronic Hepatitis B and C Virus Infection and Risk for Non-Hodgkin Lymphoma in HIV-Infected Patients. Ann. Intern. Med., 166 (1). S. 9 - 20. PHILADELPHIA: AMER COLL PHYSICIANS. ISSN 1539-3704

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Abstract

Background: Non-Hodgkin lymphoma (NHL) is the most common AIDS-defining condition in the era of antiretroviral therapy (ART). Whether chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection promote NHL in HIV-infected patients is unclear. Objective: To investigate whether chronic HBV and HCV infection are associated with increased incidence of NHL in HIV-infected patients. Design: Cohort study. Setting: 18 of 33 cohorts from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE). Patients: HIV-infected patients with information on HBV surface antigen measurements and detectable HCV RNA, or a positive HCV antibody test result if HCV RNA measurements were not available. Measurements: Time-dependent Cox models to assess risk for NHL in treatment-naive patients and those initiating ART, with inverse probability weighting to control for informative censoring. Results: A total of 52 479 treatment-naive patients (1339 [2.6%] with chronic HBV infection and 7506 [14.3%] with HCV infection) were included, of whom 40 219 (77%) later started ART. The median follow-up was 13 months for treatment-naive patients and 50 months for those receiving ART. A total of 252 treatment-naive patients and 310 treated patients developed NHL, with incidence rates of 219 and 168 cases per 100 000 person-years, respectively. The hazard ratios for NHL with HBV and HCV infection were 1.33 (95% CI, 0.69 to 2.56) and 0.67 (CI, 0.40 to 1.12), respectively, in treatment-naive patients and 1.74 (CI, 1.08 to 2.82) and 1.73 (CI, 1.21 to 2.46), respectively, in treated patients. Limitation: Many treatment-naive patients later initiated ART, which limited the study of the associations of chronic HBV and HCV infection with NHL in this patient group. Conclusion: In HIV-infected patients receiving ART, chronic coinfection with HBV and HCV is associated with an increased risk for NHL.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wang, Qing UNSPECIFIED UNSPECIFIED UNSPECIFIED De Luca, Andrea UNSPECIFIED orcid.org/0000-0002-9561-9193 UNSPECIFIED Smith, Colette UNSPECIFIED orcid.org/0000-0003-2847-3355 UNSPECIFIED Zangerle, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Sambatakou, Helen UNSPECIFIED UNSPECIFIED UNSPECIFIED Bonnet, Fabrice UNSPECIFIED UNSPECIFIED UNSPECIFIED Smit, Colette UNSPECIFIED UNSPECIFIED UNSPECIFIED Schommers, Philipp UNSPECIFIED orcid.org/0000-0003-3375-6800 UNSPECIFIED Thornton, Alicia UNSPECIFIED UNSPECIFIED UNSPECIFIED Berenguer, Juan UNSPECIFIED orcid.org/0000-0001-8541-8200 UNSPECIFIED Peters, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Spagnuolo, Vincenzo UNSPECIFIED orcid.org/0000-0002-9656-7217 UNSPECIFIED Ammassari, Adriana UNSPECIFIED orcid.org/0000-0002-0284-0340 UNSPECIFIED Antinori, Andrea UNSPECIFIED orcid.org/0000-0003-2121-4684 UNSPECIFIED Roldan, Eugenia Quiros UNSPECIFIED UNSPECIFIED UNSPECIFIED Mussini, Cristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Miro, Jose M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Konopnicki, Deborah UNSPECIFIED UNSPECIFIED UNSPECIFIED Fehr, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Campbell, Maria A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Termote, Monique UNSPECIFIED UNSPECIFIED UNSPECIFIED Bucher, Heiner C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-242806
DOI:	10.7326/M16-0240
Journal or Publication Title:	Ann. Intern. Med.
Volume:	166
Number:	1
Page Range:	S. 9 - 20
Date:	2017
Publisher:	AMER COLL PHYSICIANS
Place of Publication:	PHILADELPHIA
ISSN:	1539-3704
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTERFERON PLUS RIBAVIRIN; ANTIRETROVIRAL THERAPY; INVERSE PROBABILITY; IMMUNE ACTIVATION; INDIVIDUALS; COINFECTION; SURVIVAL; EPIDEMIOLOGY; METAANALYSIS; RECOVERY Multiple languages Medicine, General & Internal Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24280