Universität zu Köln

Pohl, Anna, Meyer, Corinna Maria, Deckers, Annika, Eckmann, Teresa, Barthel, Joachim, Huber, Walter, Habel, Ute ORCID: 0000-0003-0703-7722, Willmes, Klaus and Abel, Stefanie (2017). Training-related changes of brain activation for speech production in healthy speakers - a longitudinal fMRI study to mimic aphasia therapy. Aphasiology, 31 (5). S. 495 - 519. ABINGDON: ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD. ISSN 1464-5041

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Abstract

Background: Re-learning of lexical entries is fundamental to rehabilitation of the common word finding deficits in language disorders after brain damage. Previous studies examined and compared neural correlates of speech production and word learning in aphasic and healthy speakers, but longitudinal control studies were rarely set out to mimic the lexical confusion and therapeutic remediation in aphasia. Aims: Thus, we aimed to examine functional brain organisation before (familiar word naming), during (learning phase) and after (consolidation phase) standardised training of speech production modulated by aphasia therapy. Methods & Procedures: During the first functional magnetic resonance imaging (fMRI) measurement, participants were asked to name pictures using familiar words; during learning and in the consolidation phase, they were asked to name pictures using newly acquired pseudowords. To examine differential involvement of brain areas dependent on learning and consolidation success, we followed up activations for finally correctly learned (CoL) items between fMRI measurements, and compared activation during naming of CoL versus finally not learned (NoL) items at each measurement. Outcomes & Results: Naming accuracy of participants improved significantly. Although performance increase until the second fMRI measurement was minor, brain activation was present for CoL in comparison to NoL items in right hemisphere homologues of fronto-temporal language-related areas in this phase. Comparing learning with consolidation phases for pseudowords, naming CoL items was accompanied by activation in areas related to monitoring and selection between multiple lexical competitors, and in the right posterior middle temporal gyrus. Conversely, activation specific to the consolidation phase, and also to CoL items in that phase, consisted of a widely distributed network involving areas associated with motor, language and consolidation processes. Activation in right supramarginal and left superior temporal gyrus was related to individual learning success. Conclusions: We were able to demonstrate phase-and performance-dependent activation differences in various areas of the speech production network, which were in part correlated with learning success. The observed similarities to therapy-induced activation changes in aphasia reveal that the novel paradigm is useful in mimicking therapy and may uncover compensatory mechanisms specific to aphasia.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pohl, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Corinna Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Deckers, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Eckmann, Teresa UNSPECIFIED UNSPECIFIED UNSPECIFIED Barthel, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Huber, Walter UNSPECIFIED UNSPECIFIED UNSPECIFIED Habel, Ute UNSPECIFIED orcid.org/0000-0003-0703-7722 UNSPECIFIED Willmes, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Abel, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-242949
DOI:	10.1080/02687038.2016.1206652
Journal or Publication Title:	Aphasiology
Volume:	31
Number:	5
Page Range:	S. 495 - 519
Date:	2017
Publisher:	ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1464-5041
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LANGUAGE CONTROL; ANTERIOR; IMPLICIT; REPRESENTATIONS; REORGANIZATION; INTERFERENCE; ARTICULATION; SELECTION; LEARNERS; ANATOMY Multiple languages Audiology & Speech-Language Pathology; Linguistics; Clinical Neurology; Rehabilitation Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24294