Universität zu Köln

Tatsuta, Takashi and Langer, Thomas ORCID: 0000-0003-1250-1462 (2017). Intramitochondrial phospholipid trafficking. Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1862 (1). S. 81 - 90. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1879-2618

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Abstract

Mitochondrial functions and architecture rely on a defined lipid composition of their outer and inner membranes, which are characterized by a high content of non-bilayer phospholipids such as cardiolipin (CL) and phosphatidylethanolamine (PE). Mitochondrial membrane lipids are synthesized in the endoplasmic reticulum (ER) or within mitochondria from ER-derived precursor lipids, are asymmetrically distributed within mitochondria and can relocate in response to cellular stress. Maintenance of lipid homeostasis thus requires multiple lipid transport processes to be orchestrated within mitochondria. Recent findings identified members of the Ups/PRELI family as specific lipid transfer proteins in mitochondria that shuttle phospholipids between mitochondrial membranes. They cooperate with membrane organizing proteins that preserve the spatial organization of mitochondrial membranes and the formation of membrane contact sites, unravelling an intimate crosstalk of membrane lipid transport and homeostasis with the structural organization of mitochondria. This article is part of a Special Issue entitled: Lipids of Mitochondria edited by Guenther Daum. (C) 2016 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tatsuta, Takashi UNSPECIFIED UNSPECIFIED UNSPECIFIED Langer, Thomas UNSPECIFIED orcid.org/0000-0003-1250-1462 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-243019
DOI:	10.1016/j.bbalip.2016.08.006
Journal or Publication Title:	Biochim. Biophys. Acta Mol. Cell Biol. Lipids
Volume:	1862
Number:	1
Page Range:	S. 81 - 90
Date:	2017
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1879-2618
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MITOCHONDRIAL INTERMEMBRANE SPACE; PHOSPHATIDYLSERINE DECARBOXYLASE; SACCHAROMYCES-CEREVISIAE; TRANSBILAYER MOVEMENT; CARDIOLIPIN SYNTHASE; ALTERNATIVE TOPOGENESIS; MEMBRANE ORGANIZATION; OUTER-MEMBRANE; CONTACT SITE; YEAST Multiple languages Biochemistry & Molecular Biology; Biophysics; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24301