Universität zu Köln

Polcher, Alexandra, Frommann, Ingo, Koppara, Alexander, Wolfsgruber, Steffen, Jessen, Frank and Wagner, Michael ORCID: 0000-0003-2589-6440 (2017). Face-Name Associative Recognition Deficits in Subjective Cognitive Decline and Mild Cognitive Impairment. J. Alzheimers Dis., 56 (3). S. 1185 - 1197. AMSTERDAM: IOS PRESS. ISSN 1875-8908

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Abstract

Background: There is a need for more sensitive neuropsychological tests to detect subtle cognitive deficits emerging in the preclinical stage of Alzheimer's disease (AD). Associative memory is a cognitive function supported by the hippocampus and affected early in the process of AD. Objective: We developed a short computerized face-name associative recognition test (FNART) and tested whether it would detect memory impairment in memory clinic patients with mild cognitive impairment (MCI) and subjective cognitive decline (SCD). Methods: We recruited 61 elderly patients with either SCD (n = 32) or MCI (n = 29) and 28 healthy controls (HC) and compared performance on FNART, self-reported cognitive deterioration in different domains (ECog-39), and, in a reduced sample (n = 46), performance on the visual Paired Associates Learning of the CANTAB battery. Results: Asignificant effect of group on FNART test performance in the total samplewas found (p < 0.001). Planned contrasts indicated a significantly lower associative memory performance in the SCD (p = 0.001, d = 0.82) and MCI group (p < 0.001, d = 1.54), as compared to HCs, respectively. The CANTAB-PAL discriminated only between HC and MCI, possibly because of reduced statistical power. Adjusted for depression, performance on FNART was significantly related to ECog-39 Memory in SCD patients (p = 0.024) but not in MCI patients. Conclusions: Associative memory is substantially impaired in memory clinic patients with SCD and correlates specifically with memory complaints at this putative preclinical stage of AD. Further studies will need to examine the predictive validity of the FNART in SCD patients with regard to longitudinal (i.e., conversion to MCI/AD) and biomarker outcomes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Polcher, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Frommann, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Koppara, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolfsgruber, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-243567
DOI:	10.3233/JAD-160637
Journal or Publication Title:	J. Alzheimers Dis.
Volume:	56
Number:	3
Page Range:	S. 1185 - 1197
Date:	2017
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1875-8908
Language:	English
Faculty:	Faculty of Management, Economy and Social Sciences
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEUROPSYCHOLOGICAL ASSESSMENT BATTERY; SHORT-TERM-MEMORY; ALZHEIMERS-DISEASE; BINDING DEFICITS; EPISODIC MEMORY; AMYLOID BURDEN; OLDER-ADULTS; TOTAL SCORE; DEMENTIA; COMPLAINTS Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24356