Universität zu Köln

Altay, Lebriz, Jahn, Cheryl, Yorgun, Muecella Arikan, Caramoy, Albert, Schick, Tina, Hoyng, Carel B., den Hollander, Anneke I. and Fauser, Sascha (2017). Alteration of retinal layers in healthy subjects over 60 years of age until nonagenarians. Clin. Ophthalmol., 11. S. 1499 - 1504. ALBANY: DOVE MEDICAL PRESS LTD. ISSN 1177-5483

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Abstract

Purpose: To assess alterations of retinal layers in healthy subjects over 60 years old. Methods: Retinal layers of 160 healthy subjects (aged 60-100 years) without any retinal pathology were imaged using spectral domain optical coherence tomography. Mean thickness of retinal nerve fiber layer, ganglion cell/inner plexiform layer (GCLIPL), inner nuclear layer, outer plexiform layer/outer nuclear layer, photoreceptor complex (PR) and retinal thickness (RT) were measured in a 3.45 mm grid. Correlations between age and layers were estimated and linear regression equations were calculated. Different age-groups (60-69, 70-79, 80-89 years and nonagenarians, each group with 40 participants) were compared. Results: Significant age-thickness correlations were observed for GCLIPL (P<0.001, r=-0.394), PR (P<0.001, r=-0.370) and RT (P<0.001, r=-0.290). A comparison between age groups 60-69 years and nonagenarians showed no significant thickness alteration of retinal nerve fiber layer (21.80 +/- 2.18 mu m vs 22.82 +/- 2.97 mu m, P=0.163), inner nuclear layer (37.23 +/- 3.02 mu m vs 36.01 +/- 3.24 mu m, P=0.07) and outer plexiform layer/outer nuclear layer (104.95 +/- 6.56 mu m vs 104.23 +/- 7.59 mu m, P=0.567), while GCLIPL (83.35 +/- 7.35 mu m vs 74.38 +/- 9.09 mu m), PR (83.03 +/- 3.31 mu m vs 79.34 +/- 2.09 mu m) and RT (330.64 +/- 12.63 mu m vs 316.83 +/- 18.35 mu m) showed a significant decrease (P<0.001 for all). Conclusion: Our study provides normative data of alterations of retinal layers for persons aged 60 years to nonagenarians and indicates a continuous decrease of RT, PR, and GCLIPL. This data may be useful for clinical trials investigating macular diseases in older patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Altay, Lebriz UNSPECIFIED UNSPECIFIED UNSPECIFIED Jahn, Cheryl UNSPECIFIED UNSPECIFIED UNSPECIFIED Yorgun, Muecella Arikan UNSPECIFIED UNSPECIFIED UNSPECIFIED Caramoy, Albert UNSPECIFIED UNSPECIFIED UNSPECIFIED Schick, Tina UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoyng, Carel B. UNSPECIFIED UNSPECIFIED UNSPECIFIED den Hollander, Anneke I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-245796
DOI:	10.2147/OPTH.S137223
Journal or Publication Title:	Clin. Ophthalmol.
Volume:	11
Page Range:	S. 1499 - 1504
Date:	2017
Publisher:	DOVE MEDICAL PRESS LTD
Place of Publication:	ALBANY
ISSN:	1177-5483
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OPTICAL COHERENCE TOMOGRAPHY; AXIAL LENGTH; THICKNESS; NERVE; EYES; SEX; DEGENERATION; CELLS; OCT Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24579