Universität zu Köln

Manthou, Marilena, Abdulla, Diana Saad Yousif, Pavlov, Stoyan Pavlov, Jansen, Ramona, Bendella, Habib, Nohroudi, Klaus, Stein, Gregor ORCID: 0000-0002-0443-4573, Meyer, Carolin, Ozsoy, Ozlem, Ozsoy, Umut, Kandemir, Yasemin Behram, Sarikcioglu, Levent ORCID: 0000-0002-0825-6225, Semler, Oliver, Schoenau, Eckhard, Dunlop, Sarah ORCID: 0000-0002-1306-3962 and Angelov, Doychin Nikolov (2017). Whole body vibration (WBV) following spinal cord injury (SCI) in rats: Timing of intervention. Restor. Neurol. Neurosci., 35 (2). S. 185 - 217. AMSTERDAM: IOS PRESS. ISSN 1878-3627

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Abstract

Background: Following spinal cord injury (SCI), exercise training provides a wide range of benefits and promotes activitydependent synaptic plasticity. Whole body vibration (WBV) in SCI patients improves walking and spasticity as well as bone and muscle mass. However, little is known about the effects of timing or frequency of intervention. Objective: To determine which WBV-onset improves locomotor and bladder functions and influences synaptic plasticity beneficially. Methods: SCI was followed by WBV starting 1, 7, 14, 28 days after injury (WBV1, WBV7, etc.) and continued for 12 weeks. Intact animals and those receiving SCI but no WBV (No WBV), SCI plus WBV twice daily (2xWBV) and SCI followed by passive hindlimb flexion-extension (PFE) served as controls. Locomotor [BBB rating, foot stepping angle (FSA) and rump-height index (RHI)] as well as bladder function were determined at 1, 3, 6, 9, and 12 weeks. Following perfusion fixation at 12 weeks, lesion volume and immunofluorescence for astrogliosis (GFAP), microglia (IBA1) and synaptic vesicles (synaptophysin, SYN) were determined. Results: Compared to the No WBV group, the WB7 and WBV14 groups showed significantly faster speeds of BBB score recovery though this effect was temporary. Considering RHI we detected a sustained improvement in the WBV14 and PFE groups. Bladder function was better in the WBV14, WBV28, 2xWBV and PFE groups. Synaptophysin levels improved in response to WBV7 and WBV14, but worsened after WBV28 in parallel to an increased IBA1 expression. Correlation- and principal components analysis revealed complex relationships between behavioural (BBB, FSA, RHI) and morphological (GFAP, IBA1, SYN) measurements. Conclusions: WBV started 14 days after SCI provides the most benefit (RHI, bladder); starting at 1day after SCI provides no benefit and starting at 28 days may be detrimental. Increasing the intensity of WBV to twice daily did not provide additional benefit.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Manthou, Marilena UNSPECIFIED UNSPECIFIED UNSPECIFIED Abdulla, Diana Saad Yousif UNSPECIFIED UNSPECIFIED UNSPECIFIED Pavlov, Stoyan Pavlov UNSPECIFIED UNSPECIFIED UNSPECIFIED Jansen, Ramona UNSPECIFIED UNSPECIFIED UNSPECIFIED Bendella, Habib UNSPECIFIED UNSPECIFIED UNSPECIFIED Nohroudi, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Stein, Gregor UNSPECIFIED orcid.org/0000-0002-0443-4573 UNSPECIFIED Meyer, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Ozsoy, Ozlem UNSPECIFIED UNSPECIFIED UNSPECIFIED Ozsoy, Umut UNSPECIFIED UNSPECIFIED UNSPECIFIED Kandemir, Yasemin Behram UNSPECIFIED UNSPECIFIED UNSPECIFIED Sarikcioglu, Levent UNSPECIFIED orcid.org/0000-0002-0825-6225 UNSPECIFIED Semler, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenau, Eckhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Dunlop, Sarah UNSPECIFIED orcid.org/0000-0002-1306-3962 UNSPECIFIED Angelov, Doychin Nikolov UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-246668
DOI:	10.3233/RNN-160691
Journal or Publication Title:	Restor. Neurol. Neurosci.
Volume:	35
Number:	2
Page Range:	S. 185 - 217
Date:	2017
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1878-3627
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MUSCLE STRENGTH; SYNAPTIC PLASTICITY; FUNCTIONAL RECOVERY; UP-REGULATION; RATING-SCALE; OLDER-ADULTS; H-REFLEX; EXERCISE; INDIVIDUALS; BDNF Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24666