Universität zu Köln

Marshall-Goebel, Karina ORCID: 0000-0002-5240-7625, Mulder, Edwin, Bershad, Eric, Laing, Charles ORCID: 0000-0002-2367-2323, Eklund, Anders, Malm, Jan ORCID: 0000-0001-6451-1940, Stern, Claudia and Rittweger, Jorn ORCID: 0000-0002-2223-8963 (2017). Intracranial and Intraocular Pressure During Various Degrees of Head-Down Tilt. Aerosp. Med.Hum. Perform., 88 (1). S. 10 - 17. ALEXANDRIA: AEROSPACE MEDICAL ASSOC. ISSN 2375-6322

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Abstract

BACKGROUND: More than half of astronauts develop ophthalmic changes during long-duration spaceflight consistent with an abnormal intraocular and intracranial pressure (IOP, ICP) difference. The aim of our study was to assess IOP and ICP during head-down tilt (HDT) and the additive or attenuating effects of 1% CO2 and lower body negative pressure (LBNP). METHODS: In Experiment I, IOP and ICP were measured in nine healthy subjects after 3.5 h HDT in five conditions: -6 degrees, -12 degrees, and -18 degrees HDT, -12 degrees with 1% CO2, and -12 degrees with -20 mmHg LBNP. In Experiment II, IOP was measured in 16 healthy subjects after 5 min tilt at +12 degrees, 0 degrees, -6 degrees, -12 degrees, -18 degrees, and -24 degrees, with and without-40 mmHg LBNP. RESULTS: ICP was only found to increase from supine baseline during -18 degrees HDT (9.2 +/- 0.9 and 14.4 +/- 1 mmHg, respectively), whereas IOP increased from 15.7 +/- 0.3 mmHg at 0 degrees to 17.9 +/- 0.4 mmHg during -12 degrees HDT and from 15.3 +/- 0.4 mmHg at 0 degrees to 18.7 +/- 0.4 mmHg during-18 degrees HDT. The addition of -20 mmHg LBNP or 1% CO2 had no further effects on ICP or IOP. However, the use of -40 mmHg LBNP during HDT lowered IOP back to baseline values, except at 24 degrees HDT. DISCUSSION: A small, posterior intraocular-intracranial pressure difference (IOP > ICP) is maintained during HDT, and a sustained or further decreased difference may lead to structural changes in the eye in real and simulated microgravity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Marshall-Goebel, Karina UNSPECIFIED orcid.org/0000-0002-5240-7625 UNSPECIFIED Mulder, Edwin UNSPECIFIED UNSPECIFIED UNSPECIFIED Bershad, Eric UNSPECIFIED UNSPECIFIED UNSPECIFIED Laing, Charles UNSPECIFIED orcid.org/0000-0002-2367-2323 UNSPECIFIED Eklund, Anders UNSPECIFIED UNSPECIFIED UNSPECIFIED Malm, Jan UNSPECIFIED orcid.org/0000-0001-6451-1940 UNSPECIFIED Stern, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Rittweger, Jorn UNSPECIFIED orcid.org/0000-0002-2223-8963 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-248102
DOI:	10.3357/AMHP.4653.2017
Journal or Publication Title:	Aerosp. Med.Hum. Perform.
Volume:	88
Number:	1
Page Range:	S. 10 - 17
Date:	2017
Publisher:	AEROSPACE MEDICAL ASSOC
Place of Publication:	ALEXANDRIA
ISSN:	2375-6322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VENOUS-PRESSURE; FLUID SHIFTS; SPACE; HYPERTENSION; MICROGRAVITY; EYE; PAPILLEDEMA; SPACEFLIGHT; GLAUCOMA Multiple languages Biophysics; Public, Environmental & Occupational Health; Medicine, Research & Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24810