Universität zu Köln

Chivu-Economescu, Mihaela and Rubach, Martin (2017). Hematopoietic Stem Cells Therapies. Curr. Stem Cell Res. Ther., 12 (2). S. 124 - 134. SHARJAH: BENTHAM SCIENCE PUBL LTD. ISSN 2212-3946

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Abstract

Stem cell-based therapies are recognized as a new way to treat various diseases and injuries, with a wide range of health benefits. The goal is to heal or replace diseased or destroyed organs or body parts with healthy new cells provided by stem cell transplantation. The current practical form of stem cell therapy is the hematopoietic stem cells transplant applied for the treatment of hematological disorders. There are over 2100 clinical studies in progress concerning hematopoietic stem cell therapies. All of them are using hematopoietic stem cells to treat various diseases like: cancers, leukemia, lymphoma, cardiac failure, neural disorders, auto-immune diseases, immunodeficiency, metabolic or genetic disorders. Several challenges are to be addressed prior to developing and applying large scale cell therapies: 1) to explain and control the mechanisms of differentiation and development toward a specific cell type needed to treat the disease, 2) to obtain a sufficient number of desired cell type for transplantation, 3) to overcome the immune rejection and 4) to show that transplanted cells fulfill their normal functions in vivo after transplants.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Chivu-Economescu, Mihaela UNSPECIFIED UNSPECIFIED UNSPECIFIED Rubach, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-248134
DOI:	10.2174/1574888X10666151026114241
Journal or Publication Title:	Curr. Stem Cell Res. Ther.
Volume:	12
Number:	2
Page Range:	S. 124 - 134
Date:	2017
Publisher:	BENTHAM SCIENCE PUBL LTD
Place of Publication:	SHARJAH
ISSN:	2212-3946
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UMBILICAL-CORD BLOOD; EX-VIVO EXPANSION; GENE-THERAPY; BONE-MARROW; MYOCARDIAL-INFARCTION; TRANSPLANTATION; DISEASE; DIFFERENTIATION; COMBINATION; AUTOIMMUNE Multiple languages Cell & Tissue Engineering; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24813