Universität zu Köln

Behringer, Karolin, Goergen, Helen, Mueller, Horst, Thielen, Indra, Brillant, Corinne, Kreissl, Stefanie, Halbsguth, Teresa Veronika, Meissner, Julia, Greil, Richard, Moosmann, Peter, Shonukan, Oluwatoyin, Rueffer, Jens Ulrich, Flechtner, Hans-Henning, Fuchs, Michael, Diehl, Volker, Engert, Andreas and Borchmann, Peter (2016). Cancer-Related Fatigue in Patients With and Survivors of Hodgkin Lymphoma: The Impact on Treatment Outcome and Social Reintegration. J. Clin. Oncol., 34 (36). S. 4329 - 4346. ALEXANDRIA: AMER SOC CLINICAL ONCOLOGY. ISSN 1527-7755

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Abstract

Purpose Cancer-related fatigue occurs frequently in patients with Hodgkin lymphoma (HL) and has a major impact on their quality of life. We hypothesized that severe fatigue (sFA) might have an impact on patients' treatment outcome and social reintegration. Methods Of 5,306 patients enrolled in the German Hodgkin Study Group's fifth generation of clinical trials in HL (HD13, HD14, and HD15; nonqualified and older [>60 years] patients excluded), 4,529 provided data on health-related quality of life. We describe sFA (defined as a score >= 50 on the 0 to 100 scale from the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30) before and up to 9 years after therapy and analyze its impact on treatment outcome and social reintegration. Results The proportion of patients reporting sFA was 37% at baseline and ranged from 20% to 24% during follow-up. Baseline sFA was associated with significantly impaired progression-free survival and a trend to impaired overall survival, which can be overcome in patients receiving highly effective HL therapies as applied in our fifth-generation trials. Our analysis revealed a significant negative association of sFA and employment in survivors: 5 years after therapy, 51% and 63% of female and male survivors, respectively, with sFA were working or in professional education, compared with 78% and 90% without sFA, respectively (P < .001 adjusted for age, sex, stage, baseline employment status, and treatment outcome). sFA was also associated with financial problems and the number of visits to a general practitioner and medical specialists. Conclusion sFA is an important factor preventing survivors from social reintegration during follow-up. This observation underscores the need to address fatigue as a significant diagnosis when treating patients with and survivors of cancer. (C) 2016 by American Society of Clinical Oncology

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Behringer, Karolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Goergen, Helen UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Horst UNSPECIFIED UNSPECIFIED UNSPECIFIED Thielen, Indra UNSPECIFIED UNSPECIFIED UNSPECIFIED Brillant, Corinne UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreissl, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Halbsguth, Teresa Veronika UNSPECIFIED UNSPECIFIED UNSPECIFIED Meissner, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Greil, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Moosmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Shonukan, Oluwatoyin UNSPECIFIED UNSPECIFIED UNSPECIFIED Rueffer, Jens Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Flechtner, Hans-Henning UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuchs, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Diehl, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Engert, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Borchmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-252326
DOI:	10.1200/JCO.2016.67.7450
Journal or Publication Title:	J. Clin. Oncol.
Volume:	34
Number:	36
Page Range:	S. 4329 - 4346
Date:	2016
Publisher:	AMER SOC CLINICAL ONCOLOGY
Place of Publication:	ALEXANDRIA
ISSN:	1527-7755
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-OF-LIFE; RANDOMIZED CONTROLLED-TRIAL; COGNITIVE-BEHAVIOR THERAPY; NON-INFERIORITY TRIAL; DISEASE SURVIVORS; CLINICAL-TRIALS; BREAST-CANCER; OPEN-LABEL; EXERCISE; ONCOLOGY Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25232