Universität zu Köln

Bischof, Gerard N., Rodrigue, Karen M., Kennedy, Kristen M., Devous, Michael D., Sr. and Park, Denise C. (2016). Amyloid deposition in younger adults is linked to episodic memory performance. Neurology, 87 (24). S. 2562 - 2567. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1526-632X

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Abstract

Objective: To examine the relationship of beta-amyloid (A beta) deposition to episodic memory in younger (30-49 years), middle-older (50-69 years), and older adults (70-89 years). We hypothesized that subclinical levels of amyloid would be linked to memory in adults across the lifespan in a dose-dependent fashion. Of great interest was whether, within the younger group, a relationship between amyloid level and memory performance could be established. Methods: A total of 147 participants from the Dallas Lifespan Brain Study, aged 30-89, underwent PET imaging with F-18-florbetapir and cognitive assessment. We assessed the relationship between age group and amyloid and tested whether A beta differentially affected memory performance across the 3 age groups. Results: We report a significant association of age to amyloid burden for younger and middle-older adults (r = 0.57 and 0.28, respectively), but not for the oldest group, although absolute level of amyloid increased across the age groups. Importantly, the youngest group showed a significant decrease in recall (r = 20.47, p = 0.004) and recognition memory (r = -0.48, p = 0.003) as a function of increases in A beta burden, whereas this relationship was absent in the middle-older and oldest group (all p. 0.23). Conclusions: These results indicate that variance in subclinical levels of A beta in younger adults is meaningful, and suggest that higher SUVRs relative to one's peers at a younger age is not entirely benign.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bischof, Gerard N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rodrigue, Karen M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kennedy, Kristen M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Devous, Michael D., Sr. UNSPECIFIED UNSPECIFIED UNSPECIFIED Park, Denise C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-252567
DOI:	10.1212/WNL.0000000000003425
Journal or Publication Title:	Neurology
Volume:	87
Number:	24
Page Range:	S. 2562 - 2567
Date:	2016
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1526-632X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALZHEIMERS-DISEASE; BURDEN Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25256