Universität zu Köln

Hessler, Nicole, Geisel, Marie Henrike, Coassin, Stefan ORCID: 0000-0001-5677-8979, Erbel, Raimund, Heilmann, Stefanie, Hennig, Frauke, Hoffmann, Barbara, Joeckel, Karl-Heinz, Moebus, Susanne, Moskau-Hartmann, Susanna, Nuernberg, Gudrun, Nuernberg, Peter, Vens, Maren, Klockgether, Thomas, Kronenberg, Florian ORCID: 0000-0003-2229-1120, Scherag, Andre and Ziegler, Andreas (2016). Linkage and Association Analysis Identifies TRAF1 Influencing Common Carotid Intima-Media Thickness. Stroke, 47 (12). S. 2904 - 2910. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1524-4628

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Abstract

Background and Purpose-Carotid intima-media thickness is a marker for subclinical atherosclerosis that predicts subsequent clinical cardiovascular events. The aim of this study was to identify chromosomal loci with linkage or association to common carotid intima-media thickness. Methods-Nuclear families were recruited using the single parental proband sib-pair design. Genotype data were available for 546 individuals from 132 nuclear families of the Bonn IMT Family Study using the Affymetrix GeneChip Human Mapping 250K Sty chip. Multipoint logarithm of the odds (LOD) scores were determined with the quantitative trait locus statistic implemented in multipoint engine for rapid likelihood. Linkage analysis and family-based association tests were conducted. Data from 2471 German participants from the HNR (Heinz Nixdorf Recall) Study were used for subsequent replication. Results-Two new genomic regions with suggestive linkage (LOD>2) were identified on chromosome 4 (LOD=2.26) and on chromosome 17 (LOD=2.01). Previously reported linkage findings were replicated on chromosomes 13 and 14. Fifteen single nucleotide polymorhisms, located on chromosomes 4, 6, and 9, revealed P<10(-4) in the family-based association analyses. One of these signals was replicated in HNR (rs2416804, 1-sided P=1.60x10(-3), located in the gene TRAF1). Conclusions-This study presents the first genome-wide linkage and association study of common carotid intima-media thickness in the German population. Alleles of rs2416804 in TRAF1 were identified as being linked and associated with carotid intima-media thickness. Further studies are needed to evaluate the contribution of this locus to the development of atherosclerosis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hessler, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED Geisel, Marie Henrike UNSPECIFIED UNSPECIFIED UNSPECIFIED Coassin, Stefan UNSPECIFIED orcid.org/0000-0001-5677-8979 UNSPECIFIED Erbel, Raimund UNSPECIFIED UNSPECIFIED UNSPECIFIED Heilmann, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Hennig, Frauke UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Joeckel, Karl-Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Moebus, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Moskau-Hartmann, Susanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuernberg, Gudrun UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuernberg, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Vens, Maren UNSPECIFIED UNSPECIFIED UNSPECIFIED Klockgether, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Kronenberg, Florian UNSPECIFIED orcid.org/0000-0003-2229-1120 UNSPECIFIED Scherag, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Ziegler, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-254213
DOI:	10.1161/STROKEAHA.116.013943
Journal or Publication Title:	Stroke
Volume:	47
Number:	12
Page Range:	S. 2904 - 2910
Date:	2016
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1524-4628
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GENOME-WIDE ASSOCIATION; CORONARY-ARTERY-DISEASE; RHEUMATOID-ARTHRITIS; MYOCARDIAL-INFARCTION; INCREASED MORTALITY; GENE POLYMORPHISMS; KAWASAKI-DISEASE; RISK; LOCI; STROKE Multiple languages Clinical Neurology; Peripheral Vascular Disease Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25421