Universität zu Köln

Eggert, Angelika, Simon, Thorsten, von Schweinitz, Dietrich, Timmermann, Beate and Graf, Norbert ORCID: 0000-0002-2248-323X (2016). Embryonal abdominal tumors in childhood and adolescence. Onkologe, 22 (12). S. 940 - 954. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0415

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Abstract

The embryonal tumors neuroblastoma, nephroblastoma and hepatoblastoma are important differential diagnoses to be considered for abdominal neoplasms, particularly in infants. Clinical symptoms are often mild and unspecific and the proportion of incidental diagnoses is relatively high. Diagnostics, therapy and outcome Current diagnostics include assessment of specific tumor markers, defined staging analyses based on imaging and histological and molecular analyses of tumor tissue. Diagnostics and treatment are exclusively provided by specialized pediatric oncology centers with multidisciplinary expertise in the framework of defined therapy optimization trials. Whereas the outcome for patients with nephroblastoma and hepatoblastoma is very good even for metastasized disease, the long-term survival rate is < 40 % for patients with metastasized neuroblastoma. State of the art sequencing technologies enable increasingly more precise tumor classification and outcome prediction based on characteristic molecular patterns and the rational selection of experimental therapies for recurrent disease situations.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eggert, Angelika UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED von Schweinitz, Dietrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED Graf, Norbert UNSPECIFIED orcid.org/0000-0002-2248-323X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-254393
DOI:	10.1007/s00761-016-0136-z
Journal or Publication Title:	Onkologe
Volume:	22
Number:	12
Page Range:	S. 940 - 954
Date:	2016
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0415
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTERNATIONAL-SOCIETY; PULMONARY METASTASES; NEUROBLASTOMA; CLASSIFICATION; NEPHROBLASTOMA; HEPATOBLASTOMA; CHILDREN; SYSTEM; CISPLATIN; IMPROVES Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25439