Universität zu Köln

Eminaga, Okyaz, Wei, Wei, Hawley, Sarah J., Auman, Heidi, Newcomb, Lisa F., Simko, Jeff, Hurtado-Coll, Antonio, Troyer, Dean A., Carroll, Peter R., Gleave, Martin E., Lin, Daniel W., Nelson, Peter S., Thompson, Ian M., True, Lawrence D., McKenney, Jesse K., Feng, Ziding, Fazli, Ladan and Brooks, James D. (2016). MUC1 Expression by Immunohistochemistry Is Associated with Adverse Pathologic Features in Prostate Cancer: A Multi-Institutional Study. PLoS One, 11 (11). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Background The uncertainties inherent in clinical measures of prostate cancer (CaP) aggressiveness endorse the investigation of clinically validated tissue biomarkers. MUC1 expression has been previously reported to independently predict aggressive localized prostate cancer. We used a large cohort to validate whether MUC1 protein levels measured by immunohistochemistry (IHC) predict aggressive cancer, recurrence and survival outcomes after radical prostatectomy independent of clinical and pathological parameters. Material and Methods MUC1 IHC was performed on a multi-institutional tissue microarray (TMA) resource including 1,326 men with a median follow-up of 5 years. Associations with clinical and pathological parameters were tested by the Chi-square test and the Wilcoxon rank sum test. Relationships with outcome were assessed with univariable and multivariable Cox proportional hazard models and the Log-rank test. Results The presence of MUC1 expression was significantly associated with extracapsular extension and higher Gleason score, but not with seminal vesicle invasion, age, positive surgical margins or pre-operative serum PSA levels. In univariable analyses, positive MUC1 staining was significantly associated with a worse recurrence free survival (RFS) (HR: 1.24, CI 1.03-1.49, P = 0.02), although not with disease specific survival (DSS, P>0.5). On multivariable analyses, the presence of positive surgical margins, extracapsular extension, seminal vesicle invasion, as well as higher pre-operative PSA and increasing Gleason score were independently associated with RFS, while MUC1 expression was not. Positive MUC1 expression was not independently associated with disease specific survival (DSS), but was weakly associated with overall survival (OS). Conclusion In our large, rigorously designed validation cohort, MUC1 protein expression was associated with adverse pathological features, although it was not an independent predictor of outcome after radical prostatectomy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eminaga, Okyaz UNSPECIFIED UNSPECIFIED UNSPECIFIED Wei, Wei UNSPECIFIED UNSPECIFIED UNSPECIFIED Hawley, Sarah J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Auman, Heidi UNSPECIFIED UNSPECIFIED UNSPECIFIED Newcomb, Lisa F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Simko, Jeff UNSPECIFIED UNSPECIFIED UNSPECIFIED Hurtado-Coll, Antonio UNSPECIFIED UNSPECIFIED UNSPECIFIED Troyer, Dean A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Carroll, Peter R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gleave, Martin E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lin, Daniel W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nelson, Peter S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thompson, Ian M. UNSPECIFIED UNSPECIFIED UNSPECIFIED True, Lawrence D. UNSPECIFIED UNSPECIFIED UNSPECIFIED McKenney, Jesse K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Feng, Ziding UNSPECIFIED UNSPECIFIED UNSPECIFIED Fazli, Ladan UNSPECIFIED UNSPECIFIED UNSPECIFIED Brooks, James D. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-255642
DOI:	10.1371/journal.pone.0165236
Journal or Publication Title:	PLoS One
Volume:	11
Number:	11
Date:	2016
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GENE-EXPRESSION; O-GLYCOSYLATION; CELL-LINES; TISSUE; GRADE; PROGNOSIS; CARCINOMA; IMMUNITY; THERAPY; MUCINS Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25564