Universität zu Köln

Barbui, T., Thiele, J., Gisslinger, H., Finazzi, G., Vannucchi, A. M. and Tefferi, A. (2016). The 2016 revision of WHO classification of myeloproliferative neoplasms: Clinical and molecular advances. Blood Rev., 30 (6). S. 453 - 460. EDINBURGH: CHURCHILL LIVINGSTONE. ISSN 1532-1681

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Abstract

Clinical evidence supports the need of changing the diagnostic criteria of the 2008 updated WHO classification for polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). In JAK2-mutated patients who show characteristic bone marrow (BM) morphology, clinical studies demonstrated that a hemoglobin level of 16.5 g/dL in men and 16.0 g/dl for women or a hematocrit value of 49% in men and 48% in women are the optimal cut off levels for distinguishing JAIC2-mutated ET from masked/prodromal PV. Therefore BM morphology was upgraded to a major diagnostic criterion. Regarding ET the key issue was to improve standardization of prominent BM features enhancing differentiation between true ET and prefibrotic/early primary myelofibrosis (prePMF). These two entities have shown a different epidemiology and clinical outcomes. Concerning prePMF a more explicit clinical characterization of minor criteria is mandated for an improved distinction from ET and overt PMF and accurate diagnosis and outcome prediction. (C) 2016 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Barbui, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiele, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gisslinger, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Finazzi, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vannucchi, A. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tefferi, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-256726
DOI:	10.1016/j.blre.2016.06.001
Journal or Publication Title:	Blood Rev.
Volume:	30
Number:	6
Page Range:	S. 453 - 460
Date:	2016
Publisher:	CHURCHILL LIVINGSTONE
Place of Publication:	EDINBURGH
ISSN:	1532-1681
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language WORLD-HEALTH-ORGANIZATION; CHRONIC IDIOPATHIC MYELOFIBROSIS; BONE-MARROW FIBROSIS; MASKED POLYCYTHEMIA-VERA; TYPE-2 CALRETICULIN MUTATIONS; LONG-TERM SURVIVAL; ESSENTIAL THROMBOCYTHEMIA; DIAGNOSTIC-CRITERIA; EARLY/PREFIBROTIC MYELOFIBROSIS; HISTOLOGICAL CRITERIA Multiple languages Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25672