Universität zu Köln

Zhang, Yang, Xiu, Minghui, Jiang, Jinhong, He, Jianzheng, Li, Dongqin, Liang, Shiwei and Chen, Qiang (2016). Novokinin inhibits gastric acid secretion and protects against alcohol-induced gastric injury in rats. Alcohol, 56. S. 1 - 9. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1873-6823

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Abstract

Novokinin (Arg-Pro-Leu-Lys-Pro-Trp), a potent vasorelaxing and hypotensive peptide modified from ovokinin, exhibits highly selective affinity for the AT(2) receptor. However, its role in gastrointestinal functions is still not fully understood. In this study, we found that novokinin inhibited basal gastric acid secretion and protected gastric mucosa from alcohol-induced injury in a dose-related manner in rats after intracerebroventricular (i.c.v.) administration. Novokinin significantly decreased basal gastric acid output at the dose of 50 and 100 nmol/rat. The effect of novokinin on gastric acid secretion was reversed by central injection of PD 123319 (10 nmol/rat), an AT2 receptor antagonist, and peripheral injection of indomethacin (10 mg/kg), an inhibitor of prostaglandin synthesis. Meanwhile, pre-treatment with novokinin at doses of 10, 50, and 100 nmol/rat significantly reduced the alcohol-induced gastric mucosal injury compared to the ulcer-control group, which was inhibited by indomethacin (10 mg/kg). The result showed a remarkable increase in the level of prostaglandin E2 (PGE(2)), glutathione (GSH), and a decrease in malondialdehyde (MDA) after i.c.v. administration of novokinin. These findings suggest that the inhibitory effect of novokinin on gastric acid secretion is probably mediated via an AT(2) receptor-prostaglandins (PGs) pathway. The gastroprotective effect of novokinin might be attributed to the inhibition of acid secretion, the cytoprotection of PGs, and the antioxidant property. (C) 2016 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zhang, Yang UNSPECIFIED UNSPECIFIED UNSPECIFIED Xiu, Minghui UNSPECIFIED UNSPECIFIED UNSPECIFIED Jiang, Jinhong UNSPECIFIED UNSPECIFIED UNSPECIFIED He, Jianzheng UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Dongqin UNSPECIFIED UNSPECIFIED UNSPECIFIED Liang, Shiwei UNSPECIFIED UNSPECIFIED UNSPECIFIED Chen, Qiang UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-256920
DOI:	10.1016/j.alcohol.2016.08.003
Journal or Publication Title:	Alcohol
Volume:	56
Page Range:	S. 1 - 9
Date:	2016
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1873-6823
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANGIOTENSIN AT(2) RECEPTOR; PEPTIC-ULCER DISEASE; HELICOBACTER-PYLORI; GASTROINTESTINAL-TRACT; CYTO-PROTECTION; MUCOSAL INJURY; POTENT ANALOG; ETHANOL; PROSTAGLANDINS; OVOKININ(2-7) Multiple languages Substance Abuse; Pharmacology & Pharmacy; Toxicology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25692