Fauser, Sascha and Muether, Philipp S. (2016). Clinical correlation to differences in ranibizumab and aflibercept vascular endothelial growth factor suppression times. Br. J. Ophthalmol., 100 (11). S. 1494 - 1499. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-2079
Full text not available from this repository.Abstract
Aim To determine clinical correlations to intraocular vascular endothelial growth factor A (VEGF-A) suppression times (VSTs) on the treatment of neovascular age-related macular degeneration (nAMD) with ranibizumab (Lucentis) or aflibercept (Eylea). Methods Seven of 89 treatment-naive nAMD eyes showed persistent choroidal neovascular membrane (CNV) activity throughout a spectral domain optical coherence tomography (SD-OCT)-driven pro re nata (PRN) regimen of intravitreal ranibizumab injections over 284months. The treatment was switched to PRN aflibercept injections and patients were followed for another 152months. A total of 160 aqueous humour specimens were collected before the intravitreal injections, and their VEGF-A concentrations were assayed by Luminex multiplex bead analysis (Luminex, Austin, Texas, USA). Intraocular VEGF-A concentrations were correlated to CNV activity shown by SD-OCT. Results The mean duration of suppression of VEGF-A concentrations in aqueous humour below the lower limit of quantification of our assay was 34 +/- 5 (26-69) days for ranibizumab and 67 +/- 14 (49-89) days for aflibercept (p<0.001). The percentual reduction of central retinal volume (CRV) 6weeks after injection was higher for aflibercept compared with ranibizumab (p=0.009). The time point of clinical re-activity occurred about 50% earlier than the respective VST for each ranibizumab and aflibercept. Conclusions The VST under aflibercept treatment exceeded that under ranibizumab treatment by a factor of 2. This difference correlated with differential clinical CRV reduction 6weeks after the respective injection. For both medications, clinical activity was found at a time point as early as 50% of the individual VST. Trial registration number NCT01213667, post-results
Item Type: | Journal Article | ||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-256935 | ||||||||||||
DOI: | 10.1136/bjophthalmol-2015-308264 | ||||||||||||
Journal or Publication Title: | Br. J. Ophthalmol. | ||||||||||||
Volume: | 100 | ||||||||||||
Number: | 11 | ||||||||||||
Page Range: | S. 1494 - 1499 | ||||||||||||
Date: | 2016 | ||||||||||||
Publisher: | BMJ PUBLISHING GROUP | ||||||||||||
Place of Publication: | LONDON | ||||||||||||
ISSN: | 1468-2079 | ||||||||||||
Language: | English | ||||||||||||
Faculty: | Unspecified | ||||||||||||
Divisions: | Unspecified | ||||||||||||
Subjects: | no entry | ||||||||||||
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Refereed: | Yes | ||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/25693 |
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