Schmack, Bastian, Weymann, Alexander, Mohite, Prashant ORCID: 0000-0001-5533-3089, Saez, Diana Garcia, Zych, Bartlomiej, Sabashnikov, Anton ORCID: 0000-0002-6289-1035, Zeriouh, Mohamed, Schamroth, Joel, Koch, Achim, Soresi, Simona, Ananiadou, Olga, De Robertis, Fabio, Karck, Matthias, Simon, Andre Ruediger and Popov, Aron Frederik (2016). Contemporary review of the organ care system in lung transplantation: potential advantages of a portable ex-vivo lung perfusion system. Expert Rev. Med. Devices, 13 (11). S. 1035 - 1042. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1745-2422

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Abstract

Introduction: Lung transplantation remains the definite treatment for various end-stage lung diseases. Cold flush perfusion, the standard method for organ procurement has severe limitations. Organ Care System (OCS; TransMedics, Inc., Andover, USA) is an approved method to preserve hearts for transplantation that allows for greatly reduced cold ischemic time. Consequently, the use of an adapted OCS lung as a portable full ex-vivo lung perfusion system in lung transplantation is currently under close evaluation.Areas covered: The aim of this article is to review the advantages and the role of the OCS in the field of lung transplantation by reviewing the latest literature and evaluating this novel procurement technique in the context of conventional methods like cold flush and regular ex-vivo lung perfusion.Expert commentary: The use of OCS in the field of lung transplantation has great potential for improved patients outcomes and is justified in cases with (i) marginal donor lungs, (ii) foreseeable long time of transportation (iii) high-risk recipient or donor /recipient profiles, particularly in the setting of an overall increasing need for suitable donor organs. Results from two major multi-centre prospective studies are pending to objectively assess the possible advantages of this portable ex-vivo lung perfusion system.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schmack, BastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weymann, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mohite, PrashantUNSPECIFIEDorcid.org/0000-0001-5533-3089UNSPECIFIED
Saez, Diana GarciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zych, BartlomiejUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sabashnikov, AntonUNSPECIFIEDorcid.org/0000-0002-6289-1035UNSPECIFIED
Zeriouh, MohamedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schamroth, JoelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koch, AchimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soresi, SimonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ananiadou, OlgaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Robertis, FabioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karck, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simon, Andre RuedigerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Popov, Aron FrederikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-256950
DOI: 10.1080/17434440.2016.1243464
Journal or Publication Title: Expert Rev. Med. Devices
Volume: 13
Number: 11
Page Range: S. 1035 - 1042
Date: 2016
Publisher: TAYLOR & FRANCIS LTD
Place of Publication: ABINGDON
ISSN: 1745-2422
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LOW-POTASSIUM DEXTRAN; PRESERVATION SOLUTION; GRAFT FUNCTION; HEART-TRANSPLANTATION; DONOR HEARTS; DONATION; DEATH; MULTICENTER; ISCHEMIA; SURVIVALMultiple languages
Engineering, BiomedicalMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/25695

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