Universität zu Köln

von Lilienfeld-Toal, Marie, Berger, Annemarie, Christopeit, Maximilian ORCID: 0000-0003-4627-0412, Hentrich, Marcus, Heussel, Claus Peter, Kalkreuth, Jana, Klein, Michael, Kochanek, Matthias, Penack, Olaf, Hauf, Elke, Rieger, Christina, Silling, Gerda, Vehreschild, Maria, Weber, Thomas, Wolf, Hans-Heinrich, Lehners, Nicola, Schalk, Enrico ORCID: 0000-0003-1892-5098 and Mayer, Karin (2016). Community acquired respiratory virus infections in cancer patients-Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology. Eur. J. Cancer, 67. S. 200 - 213. OXFORD: ELSEVIER SCI LTD. ISSN 1879-0852

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Abstract

Background: Community acquired viruses (CRVs) may cause severe disease in cancer patients. Thus, efforts should be made to diagnose CRV rapidly and manage CRV infections accordingly. Methods: A panel of 18 clinicians from the Infectious Diseases Working Party of the German Society for Haematology and Medical Oncology have convened to assess the available literature and provide recommendations on the management of CRV infections including influenza, respiratory syncytial virus, parainfluenza virus, human metapneumovirus and adenovirus. Results: CRV infections in cancer patients may lead to pneumonia in approximately 30% of the cases, with an associated mortality of around 25%. For diagnosis of a CRV infection, combined. nasal/throat swabs or washes/aspirates give the best results and nucleic acid amplification based-techniques (NAT) should be used to detect the pathogen. Hand hygiene, contact isolation and face masks have been shown to be of benefit as general infection management. Causal treatment can be given for influenza, using a neuraminidase inhibitor, and respiratory syncytial virus, using ribavirin in addition to intravenous immunoglobulins. Ribavirin has also been used to treat parainfluenza virus and human metapneumovirus, but data are inconclusive in this setting. Cidofovir is used to treat adenovirus pneumonitis. Conclusions: CRV infections may pose a vital threat to patients with underlying malignancy. This guideline provides information on diagnosis and treatment to improve the outcome. (C) 2016 The Authors. Published by Elsevier Ltd.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code von Lilienfeld-Toal, Marie UNSPECIFIED UNSPECIFIED UNSPECIFIED Berger, Annemarie UNSPECIFIED UNSPECIFIED UNSPECIFIED Christopeit, Maximilian UNSPECIFIED orcid.org/0000-0003-4627-0412 UNSPECIFIED Hentrich, Marcus UNSPECIFIED UNSPECIFIED UNSPECIFIED Heussel, Claus Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalkreuth, Jana UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Kochanek, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Penack, Olaf UNSPECIFIED UNSPECIFIED UNSPECIFIED Hauf, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Rieger, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Silling, Gerda UNSPECIFIED UNSPECIFIED UNSPECIFIED Vehreschild, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolf, Hans-Heinrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehners, Nicola UNSPECIFIED UNSPECIFIED UNSPECIFIED Schalk, Enrico UNSPECIFIED orcid.org/0000-0003-1892-5098 UNSPECIFIED Mayer, Karin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-257382
DOI:	10.1016/j.ejca.2016.08.015
Journal or Publication Title:	Eur. J. Cancer
Volume:	67
Page Range:	S. 200 - 213
Date:	2016
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1879-0852
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM-CELL TRANSPLANTATION; HUMAN METAPNEUMOVIRUS INFECTION; INFLUENZA-A VIRUSES; SYNCYTIAL-VIRUS; PARAINFLUENZA VIRUS; RISK-FACTORS; CT FINDINGS; ADENOVIRUS INFECTIONS; H1N1 INFECTION; NASOPHARYNGEAL ASPIRATE Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25738