Konstantinides, Stavros V., Barco, Stefano ORCID: 0000-0002-2618-347X, Rosenkranz, Stephan, Lankeit, Mareike ORCID: 0000-0001-5211-7997, Held, Matthias, Gerhardt, Felix, Bruch, Leonard, Ewert, Ralf, Faehling, Martin, Freise, Julia, Ghofrani, Hossein-Ardeschir, Gruenig, Ekkehard, Halank, Michael, Heydenreich, Nadine, Hoeper, Marius M., Leuchte, Hanno H., Mayer, Eckhard, Meyer, F. Joachim, Neurohr, Claus, Opitz, Christian, Pinto, Antonio, Seyfarth, Hans-Juergen, Wachter, Rolf ORCID: 0000-0003-2231-2200, Zaepf, Bianca, Wilkens, Heinrike ORCID: 0000-0002-7789-8563, Binder, Harald ORCID: 0000-0002-5666-8662 and Wild, Philipp S. (2016). Late outcomes after acute pulmonary embolism: rationale and design of FOCUS, a prospective observational multicenter cohort study. J. Thromb. Thrombolysis, 42 (4). S. 600 - 610. DORDRECHT: SPRINGER. ISSN 1573-742X

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Abstract

Acute pulmonary embolism (PE) is a frequent cause of death and serious disability. The risk of PE-associated mortality and morbidity extends far beyond the acute phase of the disease. In earlier follow-up studies, as many as 30 % of the patients died during a follow-up period of up to 3 years, and up to 50 % of patients continued to complain of dyspnea and/or poor physical performance 6 months to 3 years after the index event. The most feared 'late sequela' of PE is chronic thromboembolic pulmonary hypertension (CTEPH), the true incidence of which remains obscure due to the large margin of error in the rates reported by mostly small, single-center studies. Moreover, the functional and hemodynamic changes corresponding to early, possibly reversible stages of CTEPH, have not been systematically investigated. The ongoing Follow-Up after acute pulmonary embolism (FOCUS) study will prospectively enroll and systematically follow, over a 2-year period and with a standardized comprehensive program of clinical, echocardiographic, functional and laboratory testing, a large multicenter prospective cohort of 1000 unselected patients (all-comers) with acute symptomatic PE. FOCUS will possess adequate power to provide answers to relevant remaining questions regarding the patients' long-term morbidity and mortality, and the temporal pattern of post-PE abnormalities. It will hopefully provide evidence for future guideline recommendations regarding the selection of patients for long-term follow-up after PE, the modalities which this follow-up should include, and the findings that should be interpreted as indicating progressive functional and hemodynamic post-PE impairment, or the development of CTEPH.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Konstantinides, Stavros V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barco, StefanoUNSPECIFIEDorcid.org/0000-0002-2618-347XUNSPECIFIED
Rosenkranz, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lankeit, MareikeUNSPECIFIEDorcid.org/0000-0001-5211-7997UNSPECIFIED
Held, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerhardt, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruch, LeonardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ewert, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faehling, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Freise, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghofrani, Hossein-ArdeschirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gruenig, EkkehardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Halank, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heydenreich, NadineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoeper, Marius M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leuchte, Hanno H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mayer, EckhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, F. JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neurohr, ClausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Opitz, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pinto, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seyfarth, Hans-JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wachter, RolfUNSPECIFIEDorcid.org/0000-0003-2231-2200UNSPECIFIED
Zaepf, BiancaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilkens, HeinrikeUNSPECIFIEDorcid.org/0000-0002-7789-8563UNSPECIFIED
Binder, HaraldUNSPECIFIEDorcid.org/0000-0002-5666-8662UNSPECIFIED
Wild, Philipp S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-257532
DOI: 10.1007/s11239-016-1415-7
Journal or Publication Title: J. Thromb. Thrombolysis
Volume: 42
Number: 4
Page Range: S. 600 - 610
Date: 2016
Publisher: SPRINGER
Place of Publication: DORDRECHT
ISSN: 1573-742X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
VENOUS THROMBOEMBOLISM; EUROPEAN-SOCIETY; ARTERIAL-HYPERTENSION; CARDIOLOGY ESC; RISK-FACTORS; TASK-FORCE; GUIDELINES; ASSOCIATION; MANAGEMENT; DIAGNOSISMultiple languages
Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular DiseaseMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/25753

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