Universität zu Köln

Luchini, Claudio ORCID: 0000-0003-4901-4908, Wood, Laura D., Cheng, Liang, Nottegar, Alessia ORCID: 0000-0003-3325-8705, Stubbs, Brendon ORCID: 0000-0001-7387-3791, Solmi, Marco ORCID: 0000-0003-4877-7233, Capelli, Paola, Pea, Antonio ORCID: 0000-0002-0509-6756, Sergi, Giuseppe, Manzato, Enzo, Fassan, Matteo ORCID: 0000-0001-6515-5482, Bagante, Fabio ORCID: 0000-0002-5386-0958, Bollschweiler, Elfriede, Giacopuzzi, Simone, Kaneko, Takuma, de Manzoni, Giovanni, Barbareschi, Mattia, Scarpa, Aldo and Veronese, Nicola (2016). Extranodal extension of lymph node metastasis is a marker of poor prognosis in oesophageal cancer: a systematic review with meta-analysis. J. Clin. Pathol., 69 (11). S. 956 - 962. LONDON: BMJ PUBLISHING GROUP. ISSN 1472-4146

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Abstract

The extranodal extension (ENE) of nodal metastasis is the extension of neoplastic cells through the nodal capsule into the perinodal adipose tissue. This histological feature has recently been indicated as an important prognostic factor in different types of malignancies; in this manuscript, we aim at defining its role in the prognosis of oesophageal cancer with the tool of meta-analysis. Two independent authors searched SCOPUS and PubMed until 31 August 2015 without language restrictions. The studies with available data about prognostic parameters in subjects with oesophageal cancer, comparing patients with the presence of ENE (ENE+) versus only intranodal extension (ENE-), were considered as eligible. Data were summarised using risk ratios (RRs) for number of deaths/recurrences and HRs together with 95% CIs for time-dependent risk related to ENE+, adjusted for potential confounders. Fourteen studies were selected; they followed-up 1437 patients with oesophageal cancer for a median follow-up of 39.4months. The presence of ENE was associated with a significantly increased risk of all-cause mortality (RR=1.33; 95% CI 1.18 to 1.50, p<0.0001, I-2=49%; HR=2.72, 95% CI 2.03 to 3.64, p<0.0001, I-2=0%), cancer-specific mortality (RR=1.35; 95% CI 1.14 to 1.59, p=0.001, I-2=57%; HR=1.97, 95% CI 1.41 to 2.75, p<0.0001, I-2=41%) and of risk of recurrence (RR=1.50, 95% CI 1.20 to 1.88, p<0.0001, I-2=9%; HR=2.27, 95% CI 1.72 to 2.90, p<0.0001, I-2=0%). On the basis of these results, in oesophageal cancer, ENE should be considered from the gross sampling to the pathology report, and in future oncological staging system.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Luchini, Claudio UNSPECIFIED orcid.org/0000-0003-4901-4908 UNSPECIFIED Wood, Laura D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cheng, Liang UNSPECIFIED UNSPECIFIED UNSPECIFIED Nottegar, Alessia UNSPECIFIED orcid.org/0000-0003-3325-8705 UNSPECIFIED Stubbs, Brendon UNSPECIFIED orcid.org/0000-0001-7387-3791 UNSPECIFIED Solmi, Marco UNSPECIFIED orcid.org/0000-0003-4877-7233 UNSPECIFIED Capelli, Paola UNSPECIFIED UNSPECIFIED UNSPECIFIED Pea, Antonio UNSPECIFIED orcid.org/0000-0002-0509-6756 UNSPECIFIED Sergi, Giuseppe UNSPECIFIED UNSPECIFIED UNSPECIFIED Manzato, Enzo UNSPECIFIED UNSPECIFIED UNSPECIFIED Fassan, Matteo UNSPECIFIED orcid.org/0000-0001-6515-5482 UNSPECIFIED Bagante, Fabio UNSPECIFIED orcid.org/0000-0002-5386-0958 UNSPECIFIED Bollschweiler, Elfriede UNSPECIFIED UNSPECIFIED UNSPECIFIED Giacopuzzi, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaneko, Takuma UNSPECIFIED UNSPECIFIED UNSPECIFIED de Manzoni, Giovanni UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbareschi, Mattia UNSPECIFIED UNSPECIFIED UNSPECIFIED Scarpa, Aldo UNSPECIFIED UNSPECIFIED UNSPECIFIED Veronese, Nicola UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-257813
DOI:	10.1136/jclinpath-2016-203830
Journal or Publication Title:	J. Clin. Pathol.
Volume:	69
Number:	11
Page Range:	S. 956 - 962
Date:	2016
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1472-4146
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INVOLVEMENT; ADENOCARCINOMA; CARCINOMA; IMPACT; MANAGEMENT; BIAS Multiple languages Pathology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25781