Universität zu Köln

Boehm, Volker ORCID: 0000-0001-7588-9842 and Gehring, Niels H. ORCID: 0000-0001-7792-1164 (2016). Exon Junction Complexes: Supervising the Gene Expression Assembly Line. Trends Genet., 32 (11). S. 724 - 736. LONDON: ELSEVIER SCIENCE LONDON. ISSN 1362-4555

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Abstract

The exon junction complex (EJC) is an RNA-binding protein complex that is assembled and deposited onto mRNAs during splicing. The EJC comprises four core components that bind to not only canonical sites upstream of exon-exon junctions, but also to noncanonical sites at other positions in exons. EJC-associated proteins are recruited by the EJC at different steps of gene expression to execute the multiple functions of the EJC. Recently, new insights have been obtained into how EJCs stimulate pre-mRNA splicing, and mRNA export, translation, and degradation. Furthermore, mutations in EJC core components were shown to result in severe disorders in humans, demonstrating the critical physiological role of the EJC. Hence, the EJC has been identified as an important player in post-transcriptional gene regulation in metazoans.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Boehm, Volker UNSPECIFIED orcid.org/0000-0001-7588-9842 UNSPECIFIED Gehring, Niels H. UNSPECIFIED orcid.org/0000-0001-7792-1164 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-258019
DOI:	10.1016/j.tig.2016.09.003
Journal or Publication Title:	Trends Genet.
Volume:	32
Number:	11
Page Range:	S. 724 - 736
Date:	2016
Publisher:	ELSEVIER SCIENCE LONDON
Place of Publication:	LONDON
ISSN:	1362-4555
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NONSENSE-MEDIATED DECAY; MESSENGER-RNA DECAY; STEP-I SPLICEOSOME; CRYSTAL-STRUCTURE; MAMMALIAN-CELLS; ENHANCES TRANSLATION; HELICASE ACTIVITY; SPLICING FACTORS; BINDING PROTEIN; NUCLEAR EXPORT Multiple languages Genetics & Heredity Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25801