Universität zu Köln

Ding, Xiaolei, Bloch, Wilhelm, Iden, Sandra ORCID: 0000-0003-2333-9827, Ruegg, Markus A., Hall, Michael N., Leptin, Maria ORCID: 0000-0001-7097-348X, Partridge, Linda ORCID: 0000-0001-9615-0094 and Eming, Sabine A. (2016). mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nat. Commun., 7. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

Mammalian target of rapamycin (mTOR), a regulator of growth in many tissues, mediates its activity through two multiprotein complexes, mTORC1 or mTORC2. The role of mTOR signalling in skin morphogenesis and epidermal development is unknown. Here we identify mTOR as an essential regulator in skin morphogenesis by epidermis-specific deletion of Mtor in mice (mTOR(EKO)). mTOR(EKO) mutants are viable, but die shortly after birth due to deficits primarily during the early epidermal differentiation programme and lack of a protective barrier development. Epidermis-specific loss of Raptor, which encodes an essential component of mTORC1, confers the same skin phenotype as seen in mTOR(EKO) mutants. In contrast, newborns with an epidermal deficiency of Rictor, an essential component of mTORC2, survive despite a hypoplastic epidermis and disruption in late stage terminal differentiation. These findings highlight a fundamental role for mTOR in epidermal morphogenesis that is regulated by distinct functions for mTORC1 and mTORC2.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ding, Xiaolei UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Iden, Sandra UNSPECIFIED orcid.org/0000-0003-2333-9827 UNSPECIFIED Ruegg, Markus A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hall, Michael N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Leptin, Maria UNSPECIFIED orcid.org/0000-0001-7097-348X UNSPECIFIED Partridge, Linda UNSPECIFIED orcid.org/0000-0001-9615-0094 UNSPECIFIED Eming, Sabine A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-258146
DOI:	10.1038/ncomms13226
Journal or Publication Title:	Nat. Commun.
Volume:	7
Date:	2016
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2041-1723
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MAMMALIAN TARGET; CELL DIVISIONS; P63; DIFFERENTIATION; RICTOR; GROWTH; RAPAMYCIN; MICE; AKT; PHOSPHORYLATION Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25814