Universität zu Köln

Ehlken, Hanno, Wroblewski, Raluca, Corpechot, Christophe, Arrive, Lionel, Rieger, Tim, Hartl, Johannes, Lezius, Susanne ORCID: 0000-0002-4832-4333, Huebener, Peter ORCID: 0000-0001-7558-7625, Schulze, Kornelius, Zenouzi, Roman, Sebode, Marcial, Peiseler, Moritz ORCID: 0000-0001-6195-3866, Denzer, Ulrike W., Quaas, Alexander, Weiler-Normann, Christina, Lohse, Ansgar W., Chazouilleres, Olivier and Schramm, Christoph (2016). Validation of Transient Elastography and Comparison with Spleen Length Measurement for Staging of Fibrosis and Clinical Prognosis in Primary Sclerosing Cholangitis. PLoS One, 11 (10). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

Full text not available from this repository.

Abstract

Background Patients with primary sclerosing cholangitis (PSC) develop progressive liver fibrosis and end-stage liver disease. Non-invasive and widely available parameters are urgently needed to assess disease stage and the risk of clinical progression. Transient elastography (TE) has been reported to predict fibrosis stage and disease progression. However, these results have not been confirmed in an independent cohort and comparison of TE measurement to other non-invasive means is missing. Methods In a retrospective study we collected data from consecutive PSC patients receiving TE measurements from 2006 to 2014 (n = 139). Data from 62 patients who also underwent a liver biopsy were used to assess the performance of TE and spleen length (SL) measurement for the staging of liver fibrosis. Follow-up data from this cohort (n = 130, Hamburg) and another independent cohort (n = 80, Paris) was used to compare TE and SL as predictors of clinical outcome applying Harrel's C calculations. Results TE measurement had a very good performance for the diagnosis and exclusion of higher fibrosis stages (>= F3: AUROC 0.95) and an excellent performance for the diagnosis and exclusion of cirrhosis (F4 vs. < F4: AUROC 0.98). Single-point TE measurement had very similar predictive power for patient outcome as previously published. In a combined cohort of PSC patients (n = 210), SL measurements had a similar performance as TE for the prediction of patient outcome (5 x cross-validated Harrel's C 0.76 and 0.72 for SL and TE, respectively). Conclusions Baseline TE measurement has an excellent performance to diagnose higher fibrosis stages in PSC. Baseline measurements of SL and TE have similar usefulness as predictive markers for disease progression in patients with PSC.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ehlken, Hanno UNSPECIFIED UNSPECIFIED UNSPECIFIED Wroblewski, Raluca UNSPECIFIED UNSPECIFIED UNSPECIFIED Corpechot, Christophe UNSPECIFIED UNSPECIFIED UNSPECIFIED Arrive, Lionel UNSPECIFIED UNSPECIFIED UNSPECIFIED Rieger, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartl, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Lezius, Susanne UNSPECIFIED orcid.org/0000-0002-4832-4333 UNSPECIFIED Huebener, Peter UNSPECIFIED orcid.org/0000-0001-7558-7625 UNSPECIFIED Schulze, Kornelius UNSPECIFIED UNSPECIFIED UNSPECIFIED Zenouzi, Roman UNSPECIFIED UNSPECIFIED UNSPECIFIED Sebode, Marcial UNSPECIFIED UNSPECIFIED UNSPECIFIED Peiseler, Moritz UNSPECIFIED orcid.org/0000-0001-6195-3866 UNSPECIFIED Denzer, Ulrike W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Quaas, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiler-Normann, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Lohse, Ansgar W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chazouilleres, Olivier UNSPECIFIED UNSPECIFIED UNSPECIFIED Schramm, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-258480
DOI:	10.1371/journal.pone.0164224
Journal or Publication Title:	PLoS One
Volume:	11
Number:	10
Date:	2016
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PRIMARY BILIARY-CIRRHOSIS; FATTY LIVER-DISEASE; HEPATIC-FIBROSIS; PERFORMANCE; DIAGNOSIS; CANCER; RISK Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25848