Universität zu Köln

Biehl, L. M., Huth, A., Panse, J., Kraemer, C., Hentrich, M., Engelhardt, M., Schaefer-Eckart, K., Kofla, G., Kiehl, M., Wendtner, C. -M., Karthaus, M., Ullmann, A. J., Hellmich, M., Christ, H. and Vehreschild, M. J. G. T. (2016). A randomized trial on chlorhexidine dressings for the prevention of catheter-related bloodstream infections in neutropenic patients. Ann. Oncol., 27 (10). S. 1916 - 1923. OXFORD: OXFORD UNIV PRESS. ISSN 1569-8041

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Abstract

Chlorhexidine dressings reduced the incidence of definite and probable catheter-related bloodstream infections in neutropenic patients. In contrast to previous studies, tolerance to chlorhexidine and control dressings was similar.Central venous catheter (CVC)-related bloodstream infections (CRBSI) are a frequent cause of morbidity and mortality in patients with chemotherapy-induced neutropenia. Chlorhexidine containing catheter securement dressings may prevent CRBSI. A multicenter randomized, controlled trial was conducted at 10 German hematology departments. We compared chlorhexidine-containing dressings with non-chlorhexidine control dressings in neutropenic patients. The primary end point was the incidence of definite CRBSI within the first 14 days (dCRBSI14) of CVC placement. Secondary end points included combined incidence of definite or probable CRBSI within 14 days (dpCRBSI14), overall (dpCRBSI), incidence of unscheduled dressing changes and adverse events. From February 2012 to September 2014, 613 assessable patients were included in the study. The incidence of dCRBSI14 was 2.6% (8/307) in the chlorhexidine and 3.9% (12/306) in the control group (P = 0.375). Both dpCRBSI14 and dpCRBSI were significantly less frequent in the study group with dpCRBSI14 in 6.5% (20/307) of the chlorhexidine group when compared with 11% (34/306) in the control group (P = 0.047), and dpCRBSI in 10.4% (32/307) versus 17% (52/306), respectively (P = 0.019). The frequency of dressing intolerance with cutaneous and soft tissue abnormalities at the contact area was similar in both groups (12.4% and 11.8%; P = 0.901). Although the trial failed its primary end point, the application of chlorhexidine containing catheter securement dressings reduces the incidence of definite or probable CRBSI in neutropenic patients. NCT01544686 (Clinicaltrials.gov).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Biehl, L. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Huth, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Panse, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kraemer, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hentrich, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Engelhardt, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaefer-Eckart, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kofla, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kiehl, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wendtner, C. -M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Karthaus, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ullmann, A. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Christ, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vehreschild, M. J. G. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-259415
DOI:	10.1093/annonc/mdw275
Journal or Publication Title:	Ann. Oncol.
Volume:	27
Number:	10
Page Range:	S. 1916 - 1923
Date:	2016
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1569-8041
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CENTRAL VENOUS CATHETERS; HEMATOLOGY; COLONIZATION; GUIDELINES; CHEMOTHERAPY; ONCOLOGY; SOCIETY; CARE Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25941