Universität zu Köln

Bendella, Habib, Brackmann, Derald E., Goldbrunner, Roland and Angelov, Doychin N. (2016). Nerve crush but not displacement-induced stretch of the intra-arachnoidal facial nerve promotes facial palsy after cerebellopontine angle surgery. Exp. Brain Res., 234 (10). S. 2905 - 2914. NEW YORK: SPRINGER. ISSN 1432-1106

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Abstract

Little is known about the reasons for occurrence of facial nerve palsy after removal of cerebellopontine angle tumors. Since the intra-arachnoidal portion of the facial nerve is considered to be so vulnerable that even the slightest tension or pinch may result in ruptured axons, we tested whether a graded stretch or controlled crush would affect the postoperative motor performance of the facial (vibrissal) muscle in rats. Thirty Wistar rats, divided into five groups (one with intact controls and four with facial nerve lesions), were used. Under inhalation anesthesia, the occipital squama was opened, the cerebellum gently retracted to the left, and the intra-arachnoidal segment of the right facial nerve exposed. A mechanical displacement of the brainstem with 1 or 3 mm toward the midline or an electromagnet-controlled crush of the facial nerve with a tweezers at a closure velocity of 50 and 100 mm/s was applied. On the next day, whisking motor performance was determined by video-based motion analysis. Even the larger (with 3 mm) mechanical displacement of the brainstem had no harmful effect: The amplitude of the vibrissal whisks was in the normal range of 50A degrees-60A degrees. On the other hand, even the light nerve crush (50 mm/s) injured the facial nerve and resulted in paralyzed vibrissal muscles (amplitude of 10A degrees-15A degrees). We conclude that, contrary to the generally acknowledged assumptions, it is the nerve crush but not the displacement-induced stretching of the intra-arachnoidal facial trunk that promotes facial palsy after cerebellopontine angle surgery in rats.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bendella, Habib UNSPECIFIED UNSPECIFIED UNSPECIFIED Brackmann, Derald E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldbrunner, Roland UNSPECIFIED UNSPECIFIED UNSPECIFIED Angelov, Doychin N. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-260888
DOI:	10.1007/s00221-016-4692-7
Journal or Publication Title:	Exp. Brain Res.
Volume:	234
Number:	10
Page Range:	S. 2905 - 2914
Date:	2016
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1106
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VESTIBULAR SCHWANNOMA SURGERY; ACOUSTIC NEUROMA SURGERY; RAT; RECOVERY; WHISKING; VIBRISSAE; INJURY; TRANSECTION; STIMULATION; COMPRESSION Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26088