Kalbe, Elke, Rehberg, Sarah Petra, Heber, Ines, Kronenbuerger, Martin, Schulz, Joerg B., Storch, Alexander, Linse, Katharina, Schneider, Christine, Graeber, Susanne, Liepelt-Scarfone, Inga, Berg, Daniela, Dams, Judith, Balzer-Geldsetzer, Monika, Hilker, Ruediger, Oberschmidt, Carola, Witt, Karsten, Schmidt, Nele, Mollenhauer, Brit, Trenkwalder, Claudia, Spottke, Annika, Roeske, Sandra, Wittchen, Hans-Ulrich ORCID: 0000-0002-6311-7711, Riedel, Oliver and Dodel, Richard (2016). Subtypes of mild cognitive impairment in patients with Parkinson's disease: evidence from the LANDSCAPE study. J. Neurol. Neurosurg. Psychiatry, 87 (10). S. 1099 - 1106. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-330X

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Abstract

Objective Inconsistent results exist regarding the cognitive profile in patients with Parkinson's disease with mild cognitive impairment (PD-MCI). We aimed at providing data on this topic from a large cohort of patients with PD-MCI. Methods Sociodemographic, clinical and neuropsychological baseline data from patients with PD-MCI recruited in the multicentre, prospective, observational DEMPARK/LANDSCAPE study were analysed. Results 269 patients with PD-MCI (age 67.8 +/- 7.4, Unified Parkinson's Disease Rating Scale (UPDRS-III) scores 23.2 +/- 11.6) were included. PD-MCI subtypes were 39.4% non-amnestic single domain, 30.5% amnestic multiple domain, 23.4% non-amnestic multiple domain and 6.7% amnestic single domain. Executive functions were most frequently impaired. The most sensitive tests to detect cognitive dysfunctions were the Modified Card Sorting Test, digit span backwards and word list learning direct recall. Multiple stepwise regression analyses showed that global cognition, gender and age, but not education or disease-related parameters predicted PD-MCI subtypes. Conclusions This study with the so far largest number of prospectively recruited patients with PD-MCI indicates that non-amnestic PD-MCI is more frequent than amnestic PD-MCI; executive dysfunctions are the most typical cognitive symptom in PD-MCI; and age, gender and global cognition predict the PD-MCI subtype. Longitudinal data are needed to test the hypothesis that patients with PD-MCI with specific cognitive profiles have different risks to develop dementia.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kalbe, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rehberg, Sarah PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heber, InesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kronenbuerger, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schulz, Joerg B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Storch, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Linse, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Graeber, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liepelt-Scarfone, IngaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berg, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dams, JudithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balzer-Geldsetzer, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hilker, RuedigerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oberschmidt, CarolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witt, KarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, NeleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mollenhauer, BritUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trenkwalder, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spottke, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roeske, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittchen, Hans-UlrichUNSPECIFIEDorcid.org/0000-0002-6311-7711UNSPECIFIED
Riedel, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dodel, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-261060
DOI: 10.1136/jnnp-2016-313838
Journal or Publication Title: J. Neurol. Neurosurg. Psychiatry
Volume: 87
Number: 10
Page Range: S. 1099 - 1106
Date: 2016
Publisher: BMJ PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1468-330X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
EARLY-STAGE; DRUG-NAIVE; MEMORY; DEMENTIA; INCIDENT; PROFILEMultiple languages
Clinical Neurology; Psychiatry; SurgeryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/26106

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