Universität zu Köln

Seymour, Ben ORCID: 0000-0003-1724-5832, Barbe, Michael, Dayan, Peter, Shiner, Tamara, Dolan, Ray and Fink, Gereon R. ORCID: 0000-0002-8230-1856 (2016). Deep brain stimulation of the subthalamic nucleus modulates sensitivity to decision outcome value in Parkinson's disease. Sci Rep, 6. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Deep brain stimulation ( DBS) of the subthalamic nucleus in Parkinson's disease is known to cause a subtle but important adverse impact on behaviour, with impulsivity its most widely reported manifestation. However, precisely which computational components of the decision process are modulated is not fully understood. Here we probe a number of distinct subprocesses, including temporal discount, outcome utility, instrumental learning rate, instrumental outcome sensitivity, reward-loss trade-offs, and perseveration. We tested 22 Parkinson's Disease patients both on and off subthalamic nucleus deep brain stimulation ( STN-DBS), while they performed an instrumental learning task involving financial rewards and losses, and an inter-temporal choice task for financial rewards. We found that instrumental learning performance was significantly worse following stimulation, due to modulation of instrumental outcome sensitivity. Specifically, patients became less sensitive to decision values for both rewards and losses, but without any change to the learning rate or reward-loss trade-offs. However, we found no evidence that DBS modulated different components of temporal impulsivity. In conclusion, our results implicate the subthalamic nucleus in a modulation of outcome value in experience-based learning and decision-making in Parkinson's disease, suggesting a more pervasive role of the subthalamic nucleus in the control of human decision-making than previously thought.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Seymour, Ben UNSPECIFIED orcid.org/0000-0003-1724-5832 UNSPECIFIED Barbe, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Dayan, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Shiner, Tamara UNSPECIFIED UNSPECIFIED UNSPECIFIED Dolan, Ray UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-262377
DOI:	10.1038/srep32509
Journal or Publication Title:	Sci Rep
Volume:	6
Date:	2016
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DECREASE IMPULSIVE CHOICE; BASAL GANGLIA; BILATERAL LESIONS; REACTION-TIME; MEDICATION; DOPAMINE; CORTEX; MODEL; TASK; FOOD Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26237