Universität zu Köln

Schilbach, Leonhard ORCID: 0000-0001-5547-8309, Derntl, Birgit, Aleman, Andre, Caspers, Svenja ORCID: 0000-0001-5083-4669, Clos, Mareike ORCID: 0000-0002-1611-9474, Diederen, Kelly M. J., Gruber, Oliver, Kogler, Lydia, Liemburg, Edith J., Sommer, Iris E., Mueller, Veronika I., Cieslik, Edna C. and Eickhoff, Simon B. ORCID: 0000-0001-6363-2759 (2016). Differential Patterns of Dysconnectivity in Mirror Neuron and Mentalizing Networks in Schizophrenia. Schizophr. Bull., 42 (5). S. 1135 - 1149. OXFORD: OXFORD UNIV PRESS. ISSN 1745-1701

Full text not available from this repository.

Abstract

Impairments of social cognition are well documented in patients with schizophrenia (SCZ), but the neural basis remains poorly understood. In light of evidence that suggests that the mirror neuron system (MNS) and the mentalizing network (MENT) are key substrates of intersubjectivity and joint action, it has been suggested that dysfunction of these neural networks may underlie social difficulties in SCZ patients. Additionally, MNS and MENT might be associated differently with positive vs negative symptoms, given prior social cognitive and symptom associations. We assessed resting state functional connectivity (RSFC) in meta-analytically defined MNS and MENT networks in this patient group. Magnetic resonance imaging (MRI) scans were obtained from 116 patients and 133 age-, gender- and movement-matched healthy controls (HC) at 5 different MRI sites. Network connectivity was analyzed for group differences and correlations with clinical symptoms. Results demonstrated decreased connectivity within the MNS and also the MENT in patients compared to controls. Notably, dysconnectivity of the MNS was related to symptom severity, while no such relationship was observed for the MENT. In sum, these findings demonstrate that differential patterns of dysconnectivity exist in SCZ patients, which may contribute differently to the interpersonal difficulties commonly observed in the disorder.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schilbach, Leonhard UNSPECIFIED orcid.org/0000-0001-5547-8309 UNSPECIFIED Derntl, Birgit UNSPECIFIED UNSPECIFIED UNSPECIFIED Aleman, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Caspers, Svenja UNSPECIFIED orcid.org/0000-0001-5083-4669 UNSPECIFIED Clos, Mareike UNSPECIFIED orcid.org/0000-0002-1611-9474 UNSPECIFIED Diederen, Kelly M. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruber, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Kogler, Lydia UNSPECIFIED UNSPECIFIED UNSPECIFIED Liemburg, Edith J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sommer, Iris E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Veronika I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cieslik, Edna C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED orcid.org/0000-0001-6363-2759 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-263696
DOI:	10.1093/schbul/sbw015
Journal or Publication Title:	Schizophr. Bull.
Volume:	42
Number:	5
Page Range:	S. 1135 - 1149
Date:	2016
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1745-1701
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STATE FUNCTIONAL CONNECTIVITY; TEMPORO-PARIETAL JUNCTION; DRUG-NAIVE SCHIZOPHRENIA; GLOBAL SIGNAL REGRESSION; DEFAULT-MODE NETWORK; VISUAL AREA MT; SOCIAL COGNITION; NEGATIVE SYMPTOMS; ALE METAANALYSIS; BIPOLAR DISORDER Multiple languages Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26369