Universität zu Köln

Cheah, Chan Y., Broeckelmann, Paul J., Chihara, Dai ORCID: 0000-0002-1153-2294, Moskowitz, Alison J., Engert, Andreas, Jerkeman, Mats, El-Galaly, Tarec C., Augustson, Bradley, Vose, Julie, Bartlett, Nancy L., Villa, Diego, Connors, Joseph M., Feldman, Tatyana, Pinnix, Chelsea C., Milgrom, Sarah A., Dabaja, Bouthaina, Oki, Yasuhiro and Fanale, Michelle A. (2016). Clinical characteristics and outcomes of patients with Hodgkin lymphoma with central nervous system involvement: An international multicenter collaboration. Am. J. Hematol., 91 (9). S. 894 - 900. HOBOKEN: WILEY. ISSN 1096-8652

Full text not available from this repository.

Abstract

Central nervous system (CNS) involvement is rare in patients with Hodgkin lymphoma (HL). Thus, the clinical features and outcomes are not well described. Cases of histologically confirmed CNS HL diagnosed between 1995 and 2015 were retrospectively identified in institutional (n=7), national (n=2), and cooperative group (n=1) databases. We screened 30,781 patients with HL in our combined databases and identified 21 patients meeting eligibility criteria, an estimated frequency of 0.07%. CNS involvement was present at initial diagnosis in 10 patients (48%) and a feature of relapsed/refractory disease in 11 (52%). Among these 11 patients, the median time from initial diagnosis of HL to development of CNS involvement was 1.9 years (range 0.4-6.6) and the median number of prior lines of therapy was 2 (range 1-7). Altogether, treatments included radiation, multiagent systemic chemotherapy, combined modality therapy, and subtotal resection. The overall response rate was 65%. After a median follow-up of 3.6 years (range 0.8-13.2) from diagnosis of CNS HL, the median PFS and OS were 7.6 and 29 months, respectively. CNS involvement as a feature of relapsed/refractory disease was adversely prognostic for both PFS and OS; however, four patients remain alive and free of relapse at 7-78 months follow-up. CNS involvement in HL is exceedingly rare and has a distinct clinical presentation with predilection for parenchymal lesions with dural extension. Around one-quarter of patients, mostly with CNS involvement at initial HL diagnosis, experience prolonged disease-free survival. (C) 2016 Wiley Periodicals, Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cheah, Chan Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Broeckelmann, Paul J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chihara, Dai UNSPECIFIED orcid.org/0000-0002-1153-2294 UNSPECIFIED Moskowitz, Alison J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Engert, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Jerkeman, Mats UNSPECIFIED UNSPECIFIED UNSPECIFIED El-Galaly, Tarec C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Augustson, Bradley UNSPECIFIED UNSPECIFIED UNSPECIFIED Vose, Julie UNSPECIFIED UNSPECIFIED UNSPECIFIED Bartlett, Nancy L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Villa, Diego UNSPECIFIED UNSPECIFIED UNSPECIFIED Connors, Joseph M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Feldman, Tatyana UNSPECIFIED UNSPECIFIED UNSPECIFIED Pinnix, Chelsea C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Milgrom, Sarah A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dabaja, Bouthaina UNSPECIFIED UNSPECIFIED UNSPECIFIED Oki, Yasuhiro UNSPECIFIED UNSPECIFIED UNSPECIFIED Fanale, Michelle A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-263721
DOI:	10.1002/ajh.24429
Journal or Publication Title:	Am. J. Hematol.
Volume:	91
Number:	9
Page Range:	S. 894 - 900
Date:	2016
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1096-8652
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PRIMARY CNS LYMPHOMA; RESPONSE CRITERIA; WORKSHOP; RELAPSE Multiple languages Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26372