Universität zu Köln

Pugliese, Martina, Loreto, Vittorio, Pompei, Simone and Tria, Francesca (2016). Exploring the evolution of pathogens organised in discrete antigenic clusters. J. Stat. Mech.-Theory Exp.. BRISTOL: IOP PUBLISHING LTD. ISSN 1742-5468

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Abstract

We present a numerical model for the evolution of pathogens organised in discrete antigenic clusters, where individuals in the same clusters have the same fitness. The fitness of each cluster is a decreasing function of the total number of cluster members appeared in the population. Cluster transition is modelled with inclusion and exclusion of dynamical epistatic effects. In both cases we observe a continuous transition, driven by the mutation rate, from a dynamics with single clusters alternating in time to the coexistence of many clusters in the population. The transition between the two regimes is investigated in terms of the key parameters of the model. We find that the location and the scaling of this transition can be explained in terms of the time of first appearance of a new cluster in the population. The presence of dynamical epistatic effects results in a shift of the value of the mutation rate where the transition occurs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pugliese, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Loreto, Vittorio UNSPECIFIED UNSPECIFIED UNSPECIFIED Pompei, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED Tria, Francesca UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-263786
DOI:	10.1088/1742-5468/2016/09/093306
Journal or Publication Title:	J. Stat. Mech.-Theory Exp.
Date:	2016
Publisher:	IOP PUBLISHING LTD
Place of Publication:	BRISTOL
ISSN:	1742-5468
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INFLUENZA; STRATEGY Multiple languages Mechanics; Physics, Mathematical Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26378