Universität zu Köln

Kaase, Martin, Schimanski, Sven, Schiller, Reinhold, Beyreiss, Bettina, Thuermer, Alexander, Steinmann, Joerg, Kempf, Volkhard A., Hess, Christina, Sobottka, Ingo, Fenner, Ines, Ziesing, Stefan, Burckhardt, Irene, von Mueller, Lutz, Hamprecht, Axel ORCID: 0000-0003-1449-5780, Tammer, Ina, Wantia, Nina, Becker, Karsten ORCID: 0000-0002-6391-1341, Holzmann, Thomas, Furitsch, Martina, Volmer, Gabriele and Gatermann, Soeren G. (2016). Multicentre investigation of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in German hospitals. Int. J. Med. Microbiol., 306 (6). S. 415 - 421. JENA: ELSEVIER GMBH, URBAN & FISCHER VERLAG. ISSN 1618-0607

Full text not available from this repository.

Abstract

Aim of this study was to determine the incidence and molecular epidemiology of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in Germany. E. coli and K. pneumoniae isolates from clinical samples which were non-susceptible to carbapenems were collected in laboratories serving 20 hospitals throughout Germany from November 2013 to April 2014. The isolates were tested for the presence of carbapenemases by PCR and phenotypic methods and typed by multilocus sequence typing. Risk factors including a previous hospitalization abroad were analysed. Carbapenemases were detected in 24 isolates from 22 patients out of 464,514 admissions. Carbapenemases included OXA-48 (n=14), KPC-2 (n = 8) and NDM-1 (n =2). Except for two K. pneumoniae isolates with ST101, all OXA-48 producing strains belonged to different clones. In contrast, half of KPC-2 producing K. pneumoniae were of ST258 and both NDM-1 producing strains were of ST11. Compared to carbapenem-susceptible controls, patients with carbapenemase-producing strains differed by a significantly higher proportion of males, a higher proportion of isolates from wound samples and a more frequent previous stay abroad in univariate analysis. This multicentre study demonstrated an incidence of carbapenemase-producing E. coli and K. pneumoniae from clinical samples in Germany of 0.047 cases per 1000 admissions. OXA-48 was more frequent than KPC-2 and NDM-1 and showed a multiclonal background. (C) 2016 Elsevier GmbH. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kaase, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schimanski, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiller, Reinhold UNSPECIFIED UNSPECIFIED UNSPECIFIED Beyreiss, Bettina UNSPECIFIED UNSPECIFIED UNSPECIFIED Thuermer, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinmann, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Kempf, Volkhard A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hess, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Sobottka, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Fenner, Ines UNSPECIFIED UNSPECIFIED UNSPECIFIED Ziesing, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Burckhardt, Irene UNSPECIFIED UNSPECIFIED UNSPECIFIED von Mueller, Lutz UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamprecht, Axel UNSPECIFIED orcid.org/0000-0003-1449-5780 UNSPECIFIED Tammer, Ina UNSPECIFIED UNSPECIFIED UNSPECIFIED Wantia, Nina UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, Karsten UNSPECIFIED orcid.org/0000-0002-6391-1341 UNSPECIFIED Holzmann, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Furitsch, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Volmer, Gabriele UNSPECIFIED UNSPECIFIED UNSPECIFIED Gatermann, Soeren G. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-263876
DOI:	10.1016/j.ijmm.2016.05.009
Journal or Publication Title:	Int. J. Med. Microbiol.
Volume:	306
Number:	6
Page Range:	S. 415 - 421
Date:	2016
Publisher:	ELSEVIER GMBH, URBAN & FISCHER VERLAG
Place of Publication:	JENA
ISSN:	1618-0607
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GRAM-NEGATIVE BACTERIA; RESISTANT ENTEROBACTERIACEAE; PREVALENCE; EMERGENCE; OUTBREAK; SPREAD; OXA-48 Multiple languages Microbiology; Virology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26387