Universität zu Köln

Heydt, C., Kostenko, A., Merkelbach-Bruse, S., Wolf, J. and Buttner, R. (2016). ALK evaluation in the world of multiplex testing: Network Genomic Medicine (NGM): the Cologne model for implementing personalised oncology. Ann. Oncol., 27. S. 25 - 35. OXFORD: OXFORD UNIV PRESS. ISSN 1569-8041

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Abstract

The Network Genomic Medicine (NGM) has established the first paradigm model for central molecular testing and clinical trial platforms enabling the delivery of decentralised therapies in a patient-oriented setting. Here we describe the structures of the network and give a summary of technologies to identify patients with anaplastic lymphoma kinase (ALK) fusion positive lung adenocarcinomas.Comprehensive molecular genotyping of lung cancers has become a key requirement for guiding therapeutic decisions. As a paradigm model of implementing next-generation comprehensive diagnostics, Network Genomic Medicine (NGM) has established central diagnostic and clinical trial platforms for centralised testing and decentralised personalised treatment in clinical practice. Here, we describe the structures of the NGM network and give a summary of technologies to identify patients with anaplastic lymphoma kinase (ALK) fusion-positive lung adenocarcinomas. As unifying test platforms will become increasingly important for delivering reliable, quick and affordable tests, the NGM diagnostic platform is currently implementing a comprehensive hybrid capture-based parallel sequencing pan-cancer assay.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heydt, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kostenko, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Merkelbach-Bruse, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolf, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Buttner, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-263957
DOI:	10.1093/annonc/mdw303
Journal or Publication Title:	Ann. Oncol.
Volume:	27
Page Range:	S. 25 - 35
Date:	2016
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1569-8041
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL LUNG-CANCER; IN-SITU HYBRIDIZATION; GENE REARRANGEMENTS; THORACIC ONCOLOGY; CLINICAL-SAMPLES; FISH; IMMUNOHISTOCHEMISTRY; ADENOCARCINOMAS; CRIZOTINIB; EXPRESSION Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26395