Universität zu Köln

Oppermann, Johannes, Bredow, Jan, Spies, Christian K., Lemken, Julia, Unglaub, Frank, Boese, Christoph K., Dargel, Jens, Eysel, Peer and Zoellner, Jan (2016). Effect of prolonged-released oxycodone/naloxone in postoperative pain management after total knee replacement: a nonrandomized prospective trial. J. Clin. Anesth., 33. S. 491 - 498. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1873-4529

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Abstract

Purpose: The purpose of this study was to examine the effect of postoperative prolonged release oxycodone/naloxone (OXN) in comparison to other opioids (control group) on the early postoperative rehabilitation outcome after total knee replacement. Methods: In a prospective, noninterventional, nonrandomized clinical trial, 80 patients were assigned to either the OXN group or a control group. Postoperative outcome and pain level at days 3, 6, 21, 35, and 6 months were evaluated using the Bowel Function Index, Brief Pain Inventory Short Form questionnaire, the Hospital for Special Surgery score, modified Larson score, and the ability to attend physiotherapy. Medications were recorded and safety analysis was done. Both groups were compared using an analysis of covariance. Results: There were no significant differences between both groups regarding pain levels. OXN group patients reported better bowel function (median values of 0.0 for the OXN group and 20.0 for the control group). No effect of treatment group (P = .19) and no treatment-by-visit interaction on Hospital for Special Surgery final score (P = .67) could be detected, but Larson function score in the early postoperative phase was significantly better in the OXN group (P = .018). The proportion of OXN group patients who were able to attend without any restriction was 58.1%. The proportions of patients in the OXN group and control group who experienced mild or moderate adverse drug reactions were 23.3% and 37.8%, respectively. There were no serious adverse drug reactions. Conclusion: In conclusion, OXN provides an effective analgesia and offers several benefits such as higher ability to participate in physiotherapy and better functional results. Incidence and severity of constipation can be reduced by using prolonged-released OXN as compared with other opioids. (C) 2016 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Oppermann, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Bredow, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Spies, Christian K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemken, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Unglaub, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Boese, Christoph K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dargel, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Eysel, Peer UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoellner, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-265166
DOI:	10.1016/j.jclinane.2016.04.002
Journal or Publication Title:	J. Clin. Anesth.
Volume:	33
Page Range:	S. 491 - 498
Date:	2016
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1873-4529
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NONCANCER PAIN; DOUBLE-BLIND; CANCER PAIN; ARTHROPLASTY; CONSTIPATION; EFFICACY; MODERATE; SURGERY; TABLETS; LONG Multiple languages Anesthesiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26516