Goldbrunner, Roland, Minniti, Giuseppe, Preusser, Matthias ORCID: 0000-0003-3541-2315, Jenkinson, Michael D., Sallabanda, Kita, Houdart, Emmanuel, von Deimling, Andreas ORCID: 0000-0002-5863-540X, Stavrinou, Pantelis ORCID: 0000-0001-8653-1395, Lefranc, Florence, Lund-Johansen, Morten, Moyal, Elizabeth Cohen-Jonathan, Brandsma, Dieta, Henriksson, Roger, Etti, Riccardo Soffi and Weller, Michael ORCID: 0000-0002-1748-174X (2016). EANO guidelines for the diagnosis and treatment of meningiomas. Lancet Oncol., 17 (9). S. E383 - 9. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1474-5488

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Abstract

Although meningiomas are the most common intracranial tumours, the level of evidence to provide recommendations for the diagnosis and treatment of meningiomas is low compared with other tumours such as high-grade gliomas. The meningioma task force of the European Association of Neuro-Oncology (EANO) assessed the scientific literature and composed a framework of the best possible evidence-based recommendations for health professionals. The provisional diagnosis of meningioma is mainly made by MRI. Definitive diagnosis, including histological classification, grading, and molecular profiling, requires a surgical procedure to obtain tumour tissue. Therefore, in many elderly patients, observation is the best therapeutic option. If therapy is deemed necessary, the standard treatment is gross total surgical resection including the involved dura. As an alternative, radiosurgery can be done for small tumours, or fractionated radiotherapy in large or previously treated tumours. Treatment concepts combining surgery and radiosurgery or fractionated radiotherapy, which enable treatment of the complete tumour volume with low morbidity, are being developed. Pharmacotherapy for meningiomas has remained largely experimental. However, antiangiogenic drugs, peptide receptor radionuclide therapy, and targeted agents are promising candidates for future pharmacological approaches to treat refractory meningiomas across all WHO grades.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Goldbrunner, RolandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Minniti, GiuseppeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Preusser, MatthiasUNSPECIFIEDorcid.org/0000-0003-3541-2315UNSPECIFIED
Jenkinson, Michael D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sallabanda, KitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Houdart, EmmanuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Deimling, AndreasUNSPECIFIEDorcid.org/0000-0002-5863-540XUNSPECIFIED
Stavrinou, PantelisUNSPECIFIEDorcid.org/0000-0001-8653-1395UNSPECIFIED
Lefranc, FlorenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lund-Johansen, MortenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moyal, Elizabeth Cohen-JonathanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brandsma, DietaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henriksson, RogerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Etti, Riccardo SoffiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weller, MichaelUNSPECIFIEDorcid.org/0000-0002-1748-174XUNSPECIFIED
URN: urn:nbn:de:hbz:38-265831
DOI: 10.1016/S1470-2045(16)30321-7
Journal or Publication Title: Lancet Oncol.
Volume: 17
Number: 9
Page Range: S. E383 - 9
Date: 2016
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1474-5488
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
FRACTIONATED STEREOTACTIC RADIOTHERAPY; RECEPTOR RADIONUCLIDE THERAPY; EXTERNAL-BEAM RADIOTHERAPY; PERITUMORAL BRAIN EDEMA; GROSS-TOTAL RESECTION; SIMPSON GRADE I; ATYPICAL MENINGIOMAS; PHASE-II; INTRACRANIAL MENINGIOMAS; ADJUVANT RADIOTHERAPYMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/26583

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